1070-64-0 Usage
Description
Ethyl 6,8-dichlorooctanoate is a colorless to pale yellow oily liquid that serves as an industrial toxin and an intermediate product in the synthesis of lipoic acid.
Uses
Used in Chemical Synthesis Industry:
Ethyl 6,8-dichlorooctanoate is used as an intermediate in the synthesis of lipoic acid, a vital antioxidant and coenzyme involved in various metabolic processes.
Used in Industrial Applications:
Ethyl 6,8-dichlorooctanoate is used as an industrial toxin, which may have potential applications in various chemical processes and manufacturing industries. However, due to its toxic nature, it must be handled with caution and proper safety measures.
Flammability and Explosibility
Notclassified
Synthesis
Dichloroethane in the organic solvent, 6-hydroxy -Chloro - octanoic acid ethyl ester with chlorinated reagent solid phosgene inN, N-dimethyl benzyl amine for the acid-binding agentEthyl 6-hydroxy-8-chlorooctanoate,Chlorination reagents,N, N-dimethylbenzylamine molar ratio1: 1.05: 0.12,The organic solvent was reacted with 6-hydroxy-8-The weight ratio of ethyl chlorocaprylate was1: 2.4 at a temperature ofN, N-dimethylbenzylamine was added dropwise at 10℃,Insulation temperature of 75 ,Insulation time 150min,In the reaction solution obtained,Water layer, water and 6 - hydroxy -8-chloro-ethyl octanoate weight ratio of 1:3, the upper organic phase.Vacuum distillation to collect vacuum 5mmHg,A temperature of 172-176℃,Ethyl 6,8-dichlorooctanoate,Product mol yield 95.68%, Purity 96.65%The bottom of the liquid base to adjust the pH value of 11,Layered,The upper layer was dewatered with sodium sulfateN, N-dimethylbenzylamine,The molar yield of the product was 96.69%Purity 99.71%.
Check Digit Verification of cas no
The CAS Registry Mumber 1070-64-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,7 and 0 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1070-64:
(6*1)+(5*0)+(4*7)+(3*0)+(2*6)+(1*4)=50
50 % 10 = 0
So 1070-64-0 is a valid CAS Registry Number.
InChI:InChI=1/C10H18Cl2O2/c1-2-14-10(13)6-4-3-5-9(12)7-8-11/h9H,2-8H2,1H3
1070-64-0Relevant articles and documents
Method for preparing 6,8-dichloroethyl caprylate
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Paragraph 0045; 0046; 0051; 0052; 0057; 0058; 0063, (2021/03/13)
The invention provides a method for preparing 6,8-dichloroethyl caprylate. As shown in the following reaction formula, the method comprises the following reaction: performing oxidative esterificationon a compound 1 to obtain a compound 2, dehydrating to generate a compound 3, performing a Prins condensation reaction to obtain a compound 4, performing hydrolysis hydrogenation to obtain a compound5, and finally performing chlorination to obtain the 6,8-dichloroethyl caprylate. The method has the characteristics of easily available raw materials, simple process, high efficiency and environmental protection.
Preparation method of ethyl 6,8-dichlorocaprylate
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Paragraph 0047; 0048; 0049, (2016/10/17)
The invention relates to a preparation method of ethyl 6,8-dichlorocaprylate, belonging to the technical field of preparation of organic compound intermediates. The preparation method comprises the steps of reacting ethyl 6-hydroxy-8-chlorocaprylate with a chlorination agent in an organic solvent by taking N,N-dimethylbenzylamine as an acid-binding agent, controlling the reaction temperature, maintaining the temperature after the reaction is finished, and controlling the temperature maintaining temperature and the temperature maintaining time to obtain reaction liquid, adding water for layering to obtain an organic phase at an upper layer, carrying out reduced pressure rectification to obtain ethyl 6,8-dichlorocaprylate, adding alkali to a lower layer to regulate pH for layering, and carrying out dehydration on the upper layer by virtue of anhydrous sodium sulphate so as to obtain N,N-dimethylbenzylamine, and recycling. By virtue of the preparation method, the chlorination capacity is improved, the yield reaches about 95%, the cycle use is realized, the discharging of wastewater is reduced, the process route is advanced, the process conditions are reasonable, the operation is simple and safe, the reaction yield is high, the production cost is relatively low, and three wastes are little.