107017-74-3 Usage
Description
(1-((tert-Butoxycarbonyl)amino)cyclopropyl)methyl methanesulfonate is a chemical compound used in organic synthesis and pharmaceutical research. It is a derivative of cyclopropylmethyl methanesulfonate, a versatile reagent often employed in the protection of amines in the presence of other functional groups. The presence of the tert-butoxycarbonyl (Boc) protecting group allows for the selective modification of the amine group and prevents unwanted reactions with other functional groups.
Uses
Used in Organic Synthesis:
(1-((tert-Butoxycarbonyl)amino)cyclopropyl)methyl methanesulfonate is used as a reagent for the selective protection and modification of amine groups in organic synthesis. The Boc protecting group enables chemists to carry out reactions on other functional groups without affecting the amine, facilitating the synthesis of complex organic compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (1-((tert-Butoxycarbonyl)amino)cyclopropyl)methyl methanesulfonate is used as a building block for the synthesis of pharmaceutical intermediates and biologically active molecules. Its ability to protect amines makes it a valuable tool in the development of new drugs and therapeutic agents.
Used in the Synthesis of Biologically Active Molecules:
(1-((tert-Butoxycarbonyl)amino)cyclopropyl)methyl methanesulfonate is also utilized in the synthesis of biologically active molecules, such as peptides, proteins, and other biomolecules. The Boc protecting group allows for the controlled assembly of these complex structures, ensuring the desired chemical and biological properties are achieved.
Check Digit Verification of cas no
The CAS Registry Mumber 107017-74-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,7,0,1 and 7 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 107017-74:
(8*1)+(7*0)+(6*7)+(5*0)+(4*1)+(3*7)+(2*7)+(1*4)=93
93 % 10 = 3
So 107017-74-3 is a valid CAS Registry Number.
107017-74-3Relevant articles and documents
Design, synthesis and pharmacological evaluation of new acyl sulfonamides as potent and selective Bcl-2 inhibitors
Liu, Xiaohua,Zhang, Yu,Huang, Wenjing,Tan, Wenfu,Zhang, Ao
, p. 443 - 454 (2018)
The antiapoptotic protein Bcl-2, overexpressed in many tumor cells, is an attractive target for potential small molecule anticancer drug discovery. Herein, we report a different structural modification approach on ABT-263 by merging the piperazinyl-phenyl fragment into a bicyclic framework leading to a series of novel analogues, among which tetrahydroisoquinoline 13 was nearly equally potent against Bcl-2 as ABT-263. Further SAR in the P4-interaction pocket affored the difluoroazetidine substituted analogue 55, which retained good Bcl-2 activity with improved Bcl-2/Bcl-xL selectivity.
ANTIVIRAL PYRIDOPYRAZINEDIONE COMPOUNDS
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Paragraph 0450; 0454; 0731; 0734, (2020/04/09)
The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by herpesviruses.
METALLO-BETA-LACTAMASE INHIBITORS
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, (2017/04/04)
The present invention relates to compounds of formula I that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.
