107021-12-5 Usage
Description
Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor, primarily used as an anti-HIV agent and antiviral medication.
Uses
Used in Pharmaceutical Industry:
Tenofovir is used as an antiretroviral agent for the treatment of HIV-1 infection. It works by inhibiting the activity of reverse transcriptase, an enzyme essential for the replication of the virus, thus suppressing the viral load and slowing down the progression of the disease.
Used in Antiviral Applications:
Tenofovir is used as an antiviral agent for the prevention and treatment of various viral infections, including hepatitis B. Its mechanism of action involves the inhibition of viral replication by targeting the reverse transcriptase enzyme, thereby reducing the spread of the virus in the body.
Check Digit Verification of cas no
The CAS Registry Mumber 107021-12-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,7,0,2 and 1 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 107021-12:
(8*1)+(7*0)+(6*7)+(5*0)+(4*2)+(3*1)+(2*1)+(1*2)=65
65 % 10 = 5
So 107021-12-5 is a valid CAS Registry Number.
InChI:InChI=1/C9H14N5O4P/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17)/t6-/m1/s1
107021-12-5Relevant articles and documents
Repurposing Antiviral Drugs for Orthogonal RNA-Catalyzed Labeling of RNA
Dey, Surjendu,Ghaem Maghami, Mohammad,H?bartner, Claudia,Lenz, Ann-Kathrin
, p. 9335 - 9339 (2020)
In vitro selected ribozymes are promising tools for site-specific labeling of RNA. Previously known nucleic acid catalysts attached fluorescently labeled adenosine or guanosine derivatives through 2′,5′-branched phosphodiester bonds to the RNA of interest. Herein, we report new ribozymes that use orthogonal substrates, derived from the antiviral drug tenofovir, and attach bioorthogonal functional groups, as well as affinity handles and fluorescent reporter units through a hydrolytically more stable phosphonate ester linkage. The tenofovir transferase ribozymes were identified by in vitro selection and are orthogonal to nucleotide transferase ribozymes. As genetically encodable functional RNAs, these ribozymes may be developed for potential cellular applications. The orthogonal ribozymes addressed desired target sites in large RNAs in vitro, as shown by fluorescent labeling of E. coli 16S and 23S rRNAs in total cellular RNA.