107027-60-1

Basic information

• Product Name: Quinoline, 2-(4-methoxyphenyl)-8-methyl-
• CAS NO: 107027-60-1
• Molecular Formula: C17H15NO
• Molecular Weight: 249.312
• Mol File: 107027-60-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Quinoline, 2-(4-methoxyphenyl)-8-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Quinoline, 2-(4-methoxyphenyl)-8-methyl-(107027-60-1)
• EPA Substance Registry System: Quinoline, 2-(4-methoxyphenyl)-8-methyl-(107027-60-1)

Safety Data

• Hazardous Substances Data: 107027-60-1(Hazardous Substances Data)

Upstream product

• 107027-47-4 2-(4-methoxy-phenyl)-8-methyl-quinoline-4-carboxylic acid 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 611-32-5 8-methylquinoline 
• 57772-50-6 2-amino-3-methylbenzyl alcohol 
• 3319-15-1 rac-1-(4-methoxyphenyl)-ethanol 
• 64-17-5 ethanol 
• 123-11-5 4-methoxy-benzaldehyde 
• 95-53-4 o-toluidine 
• 1127-59-9 7-methyl-1H-indole-2,3-dione 
• 74-86-2 acetylene 
• 14774-77-7 p-methoxyphenyllithium 

Downstream Products

• 107027-03-2 2-(4-Methoxy-phenyl)-quinoline-8-carboxylic acid (2-dimethylamino-ethyl)-amide; hydrochloride 
• 107027-72-5 2-(4-Methoxy-phenyl)-quinoline-8-carboxylic acid 

Relevant articles and documents

Direct C-H Arylation and Alkylation of Electron-Deficient Heteroaromatic Compounds with Organozinc Reagents

A direct and convenient method for the C-H arylation and alkylation of electron-deficient N-heteroarenes with readily available organozinc reagents has been developed. This transformation could be readily performed in the absence of a transition-metal catalyst and external oxidants, affording a wide range of substituted heteroarenes with good functional group tolerance in good to excellent yields. The developed simple protocol is scalable to the gram level and suitable for late-stage modification of bioactive molecules and drugs.

Three-Component Povarov Reaction with Alcohols as Alkene Precursors: Efficient Access to 2-Arylquinolines

An atom-economic and efficient approach to the synthesis of 2-arylquinolines has been developed. The protocol involves an iron-catalysed cascade N-alkylation/aerobic oxidation/Povarov reaction, and the desired quinolines were prepared in moderate to excellent yields from readily accessible anilines, aldehydes, and EtOH/nPrOH, with water as the only side-product. The aniline substrates also act as a recyclable transfer medium for EtOH/nPrOH through an in-situ N-alkylation/oxidation process. This makes EtOH/nPrOH an economical and environmentally friendly precursor of alkenes as well as the solvent.