107036-62-4

Basic information

• Product Name: 5-fluoro-2',3'-dideoxycytidine
• Synonyms: 5-fluoro-2',3'-dideoxycytidine;β-D-FddC;.beta.-D-5-F-Ddc;.beta.-D-Fddc;5-F-Ddc;Aids000043;Aids-000043;Cytidine, 2', -3', -dideoxy-5-fluoro-
• CAS NO: 107036-62-4
• Molecular Formula: C₉H₁₂FN₃O₃
• Molecular Weight: 229.2083
• Mol File: 107036-62-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 386.2°Cat760mmHg
• Flash Point: 187.4°C
• Appearance: /
• Density: 1.67g/cm³
• Vapor Pressure: 1.47E-07mmHg at 25°C
• Refractive Index: 1.665
• CAS DataBase Reference: 5-fluoro-2',3'-dideoxycytidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-fluoro-2',3'-dideoxycytidine(107036-62-4)
• EPA Substance Registry System: 5-fluoro-2',3'-dideoxycytidine(107036-62-4)

Safety Data

• Hazardous Substances Data: 107036-62-4(Hazardous Substances Data)

Usage

Description

5-fluoro-2',3'-dideoxycytidine, a synthetic analog of the nucleoside cytidine, is an antiviral agent specifically designed to combat the replication of retroviruses, most notably HIV. It functions by inhibiting the viral enzyme reverse transcriptase, which is crucial for the virus's replication process. This interference effectively prevents the production of new viral particles, thereby controlling the progression of the infection and playing a significant role in antiretroviral therapy.

Uses

Used in Pharmaceutical Industry:
5-fluoro-2',3'-dideoxycytidine is used as an antiviral agent for the treatment of HIV/AIDS. It is employed for its ability to reduce viral load and improve immune function in patients, making it a critical component of antiretroviral therapy. The drug's mechanism of action involves the disruption of the reverse transcriptase enzyme, which is essential for the replication of the virus, thereby halting the production of new viral particles and aiding in the management of the disease.

InChI:InChI=1/C9H12FN3O3/c10-6-3-13(9(15)12-8(6)11)7-2-1-5(4-14)16-7/h3,5,7,14H,1-2,4H2,(H2,11,12,15)/t5-,7+/m0/s1

Upstream product

• 107036-61-3 2',3'-dideoxy-5'-O-(trimethylacetyl)-4-thioxo-5-fluorouridine 
• 107036-58-8 1-<2'-deoxy-5'-O-(trimethylacetyl)-β-D-ribofuranosyl>-5-fluorouracil 
• 107036-60-2 2',3'-dideoxy-5'-O-(trimethylacetyl)-5-fluorouridine 
• 107036-59-9 2'-deoxy-3'-(methoxythiocarbonyl)-5'-O-(trimethylacetyl)-5-fluorouridine 
• 50-91-9 5-Fluoro-2'-deoxyuridine 
• 187458-07-7 5-({[tert-butyl(dimethyl)silyl]oxy}methyl)tetrahydrofuran-2-yl acetate 
• 56-86-0 L-glutamic acid 
• 21461-84-7 (2S)-tetrahydro-5-oxofuran-2-carboxylic acid 
• 32780-06-6 (5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran 
• 62396-80-9 (5S)-(5-tert-butyldimethylsilyloxymethyl)furan-2(5H)-one 

Relevant articles and documents

NMR studies of pyrimidinic nucleosides derived from 2,3-dideoxy-d-ribose with inhibitory activity on LINE-1 mobility

-

Potent Anti-AIDS Drugs. 2',3'-Dideoxycytidine Analogues

5-Substituted 2',3'-dideoxycytidine analogues have been synthesized and evaluated in vitro for their capabilities to protect T4+ lymphocytes from the cytopathic effects of the HTLV-III/LAV (HIV) virus, the causative agent of acquired immunodefi