107097-10-9Relevant articles and documents
Oxidation of nucleic acid related compounds by the peroxodisulfate ion
Itahara,Yoshitake,Koga,Nishino
, p. 2257 - 2264 (2007/10/02)
The treatment of nucleic acid bases, nucleosides, and nucleotides with peroxodisulfate ion in a phosphate buffer solution at pH 7.0 or water at 70-75°C was investigated. The reaction of thymine and 5-methylcytosine nucleosides and nucleotides resulted in the oxidation of the 5-methyl groups. The oxidation products from 1,3-dimethyluracils and the time-course of the reaction of uracils led to two plausible reaction mechanisms for the oxidation of uracils.
Oxidation of Thymines and Uracils with Sodium Peroxodisulfate
Itahara, Toshio,Ebihara, Reiko,Fujii, Yukiko,Tada, Miki
, p. 1319 - 1322 (2007/10/02)
Reaction of thymines with Na2S2O8 in water resulted in selective oxidation of the methyl group at 5-position of thymines.Oxidation of thymines with Na2S2O8 in hydrochloric acid gave 5-chloro-6-hydroxy-5,6-dihydrothymines and in acetic acid containing NaCl gave 6-acetoxy-5-chloro-5,6-dihydrothymines which were converted to 6-alkoxy-5-chloro-5,6-dihydrothymines with alcohols.The reaction of uracils also gave similar products together with 5-chlorouracils.