107166-90-5

Basic information

• Product Name: methyl (2E)-3-(2-methoxypyrimidin-5-yl)prop-2-enoate
• CAS NO: 107166-90-5
• Molecular Formula: C₉H₁₀N₂O₃
• Molecular Weight: 194.1873
• Mol File: 107166-90-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 339.257°C at 760 mmHg
• Flash Point: 158.977°C
• Density: 1.207g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.552
• CAS DataBase Reference: methyl (2E)-3-(2-methoxypyrimidin-5-yl)prop-2-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (2E)-3-(2-methoxypyrimidin-5-yl)prop-2-enoate(107166-90-5)
• EPA Substance Registry System: methyl (2E)-3-(2-methoxypyrimidin-5-yl)prop-2-enoate(107166-90-5)

Safety Data

• Hazardous Substances Data: 107166-90-5(Hazardous Substances Data)

Upstream product

• 101803-06-9 5-iodo-2-methoxypyrimidine 
• 292638-85-8 acrylic acid methyl ester 
• 14001-66-2 5-bromo-2-methoxypyrimidine 
• 931-63-5 2-methoxypyrimidine 

Downstream Products

• 173088-58-9 (E)-p-nitrophenyl 3-(2-methoxy-5-pyrimidinyl)acrylate 
• 221549-90-2 C₂₂H₂₀N₄O₅ 
• 1380428-67-0 2-{[2-(3-fluoro-4-{[6-(trifluoromethyl)-2-pyridinyl]oxy}phenyl)ethyl]oxy}-5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-4(1H)-pyrimidinone 
• 1380427-00-8 2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]oxy}-5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-4(1H)-pyrimidinone 
• 1380427-01-9 2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]oxy}-1-methyl-5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-4(1H)-pyrimidinone 

Relevant articles and documents

A Convenient Synthesis of Methyl (E)-β-Pyrimidinylacrylates

A convenient synthesis of methyl (E)-β-pyrimidinylacrylates 5 is described. 5-Halopyrimidines react smoothly with methyl acrylate in the presence of palladium diacetate-triphenylphosphine complex in triethylamine to afford methyl (E)-β-pyrimidinylacrylates in satisfactory yields.Using this method an improved preparation of (E)-β-(2,4-dioxo-6-methyl-1,2,3,4-tetrahydropyrimidin-5-yl)acrylic acid is reported.

New water-soluble duocarmycin derivatives: Synthesis and antitumor activity of A-ring pyrrole compounds bearing β-heteroarylacryloyl groups

A series of A-ring pyrrole compounds of duocarmycin bearing 4'-methoxy- β-heteroarylacryloyl groups were synthesized and evaluated for in vitro anticellular activity against HeLa S3 cells and in vivo antitumor activity against murine sarcoma 18