1071789-04-2Relevant articles and documents
Synthesis of triazole-oxazolidinones via a one-pot reaction and evaluation of their antimicrobial activity
Demaray, Jeffrey A.,Thuener, Jason E.,Dawson, Matthew N.,Sucheck, Steven J.
supporting information; experimental part, p. 4868 - 4871 (2009/05/27)
C-5-substituted triazole-oxazolidinones were synthesized using a bromide catalyzed cycloaddition between aryl isocyanates and epibromohydrin followed by a three-component Huisgen cycloaddition. The library of compounds was screened for antibacterial activity against Mycobacterium smegmatis ATCC 14468, Bacillus subtilis ATCC 6633, and Enterococcus faecalis ATCC 29212. Notably, the 3-(4-acetyl-phenyl)-5-(1H-1,2,3-triazol-1-yl)methyl)-oxazolidin-2-one (18) showed an MIC of 1 μg/mL against M. smegmatis ATCC 14468, fourfold lower than the MIC measured for isoniazid.