1071820-82-0

Basic information

• Product Name: 1-[3-(2-methoxyethoxycarbonyl)-2-oxopropyl]-1H-isoquinoline-2-carboxylic acid benzyl ester
• Synonyms: 1-[3-(2-methoxyethoxycarbonyl)-2-oxopropyl]-1H-isoquinoline-2-carboxylic acid benzyl ester
• CAS NO: 1071820-82-0
• Molecular Weight: 423.466
• Mol File: 1071820-82-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-[3-(2-methoxyethoxycarbonyl)-2-oxopropyl]-1H-isoquinoline-2-carboxylic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[3-(2-methoxyethoxycarbonyl)-2-oxopropyl]-1H-isoquinoline-2-carboxylic acid benzyl ester(1071820-82-0)
• EPA Substance Registry System: 1-[3-(2-methoxyethoxycarbonyl)-2-oxopropyl]-1H-isoquinoline-2-carboxylic acid benzyl ester(1071820-82-0)

Safety Data

• Hazardous Substances Data: 1071820-82-0(Hazardous Substances Data)

Upstream product

• 119-65-3 isoquinoline 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 1071820-87-5 11-hydroxy-13-azatricyclo[7.3.1.0(2,7)]trideca-2⁽⁷⁾,3,5,10-tetraene-10,13-dicarboxylic acid 13-benzyl ester 10-(2-methoxyethyl) ester 

Relevant articles and documents

Synthesis of functionalized isobenzomorphans by two-step cyclocondensation of 1,3-bis(trimethylsilyloxy)-1,3-butadienes with isoquinolines

A great variety of functionalized 7,8-benzo-anellated 9-azabicyclo-[3.3.1] nonan-3-ones were prepared by methyl or benzyl chloroformate-mediated condensation of isoquinolines with 1,3-bis(silyloxy)-1,3-butadienes and subsequent TFA-mediated cyclization. The hydroxy group could be functionalized by Suzuki reactions of the corresponding enol triflates. The N-benzyloxycarbonyl-substituted products were successfully deprotected. The decarboxylation allowed the synthesis of the parent 7,8-benzo-anellated 9-azabicyclo[3.3.1]nonan-3-ones. The products can be regarded as functionalized isobenzomorphans - simple structural analogues of morphine. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.