1072002-99-3Relevant articles and documents
Discovery of DS-6930, a potent selective PPARγ modulator. Part I: Lead identification
Shinozuka, Tsuyoshi,Tsukada, Tomoharu,Fujii, Kunihiko,Tokumaru, Eri,Shimada, Kousei,Onishi, Yoshiyuki,Matsui, Yumi,Wakimoto, Satoko,Kuroha, Masanori,Ogata, Tsuneaki,Araki, Kazushi,Ohsumi, Jun,Sawamura, Ryoko,Watanabe, Nobuaki,Yamamoto, Hideki,Fujimoto, Kazunori,Tani, Yoshiro,Mori, Makoto,Tanaka, Jun
, p. 5079 - 5098 (2018)
The lead identification of a novel potent selective PPARγ agonist, DS-6930 is reported. To avoid PPARγ-related adverse effects, a partial agonist was designed to prevent the direct interaction with helix 12 of PPARγ-LBD. Because the TZD group is known to
