107213-70-7Relevant articles and documents
Synthesis and biological evaluation of 3-amino-, 3-alkoxy- and 3-aryloxy-6-(hetero)arylpyridazines as potent antitumor agents
Sengmany, Stéphane,Sitter, Mathilde,Léonel, Eric,Le Gall, Erwan,Loirand, Gervaise,Martens, Thierry,Dubreuil, Didier,Dilasser, Florian,Rousselle, Morgane,Sauzeau, Vincent,Lebreton, Jacques,Pipelier, Muriel,Le Guével, Rémy
supporting information, p. 755 - 760 (2019/01/16)
Various 3-amino-, 3-aryloxy- and alkoxy-6-arylpyridazines have been synthesized by an electrochemical reductive cross-coupling between 3-amino-, 3-aryloxy- or 3-alkoxy-6-chloropyridazines and aryl or heteroaryl halides. In vitro antiproliferative activity
An electrochemical nickel-catalyzed arylation of 3-amino-6- chloropyridazines
Sengmany, Stephane,Vitu-Thiebaud, Arnaud,Le Gall, Erwan,Condon, Sylvie,Leonel, Eric,Thobie-Gautier, Christine,Pipelier, Muriel,Lebreton, Jacques,Dubreuil, Didier
, p. 370 - 379 (2013/03/13)
3-Amino-6-aryl- and 3-amino-6-heteroarylpyridazines have been obtained in generally good yield using a nickel-catalyzed electrochemical cross-coupling between 3-amino-6-chloropyridazines and aryl or heteroaryl halides at room temperature. Comparative experiments involving classical palladium-catalyzed reactions, such as Suzuki, Stille, or Negishi cross-couplings, reveal that the electrochemical method can constitute a reliable alternative tool for biaryl formation. A possible reaction mechanism is proposed on the basis of electrochemical analyses.
