1072227-73-6

Basic information

• Product Name: 2,2-diphenyl-2-{(S)-1-[2-(2,3-dihydro-benzofuran-5-yl)-ethyl]-pyrrolidin-3-yl}-acetic acid methyl ester
• Synonyms: 2,2-diphenyl-2-{(S)-1-[2-(2,3-dihydro-benzofuran-5-yl)-ethyl]-pyrrolidin-3-yl}-acetic acid methyl ester
• CAS NO: 1072227-73-6
• Molecular Weight: 441.57
• Mol File: 1072227-73-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,2-diphenyl-2-{(S)-1-[2-(2,3-dihydro-benzofuran-5-yl)-ethyl]-pyrrolidin-3-yl}-acetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-diphenyl-2-{(S)-1-[2-(2,3-dihydro-benzofuran-5-yl)-ethyl]-pyrrolidin-3-yl}-acetic acid methyl ester(1072227-73-6)
• EPA Substance Registry System: 2,2-diphenyl-2-{(S)-1-[2-(2,3-dihydro-benzofuran-5-yl)-ethyl]-pyrrolidin-3-yl}-acetic acid methyl ester(1072227-73-6)

Safety Data

• Hazardous Substances Data: 1072227-73-6(Hazardous Substances Data)

Upstream product

• 64089-34-5 2-chloro-1-(2,3-dihydrobenzofuran-5-yl)ethanone 
• 3469-00-9 methyl 2,2-diphenylacetate 
• 1072227-66-7 methyl 2,2-diphenyl-2-((S)-1-tosyl-pyrrolidin-3-yl)-acetate 
• 943034-50-2 2-(2,3-dihydrobenzofuran-5-yl)ethylchloride 
• 127264-14-6 2,3-dihydro-5-(2-bromoethyl)benzofuran 
• 1072227-71-4 2,2-diphenyl-2-((S)-pyrrolidin-3-yl)-acetic acid methyl ester 

Downstream Products

• 133099-04-4 darifenacin 
• 133099-07-7 (S)-darifenacin hydrobromide 

Relevant articles and documents

NOVEL AND IMPROVED PROCESSES FOR THE PREPARATION OF INTERMEDIATES OF DARIFENACIN, DARIFENACIN AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS

The present invention relates to novel and improved processes for the preparation of intermediates of darifenacin, darifenacin and its pharmaceutically acceptable salts. Darifenacin is chemically known as 3 -(S)-(-)-(l -carbamoyl- 1,1 -diphenylmethyl)-l- [2- (2,3-dihydro benzofuran-5-yl)ethyl]pyrrolidine and represented by formula-2. The invention also relates to the novel polymorphs of the pharmaceutically acceptable salts of darifenacin and the methods for their re aration.