107223-83-6Relevant articles and documents
Thionation with the reagent combination of phosphorus pentasulfide and hexamethyldisiloxane
Curphey, Thomas J.
, p. 6461 - 6473 (2002)
The combination of P4S10 and hexamethyldisiloxane efficiently converts esters, lactones, amides, lactams, and ketones to their corresponding thiono derivatives. In the presence of elemental sulfur, 3-oxoesters are converted to dithiolethiones by this reagent. Yields are comparable to or superior to those obtained with Lawesson's reagent. The method has the advantage that reagent-derived byproducts may be removed by a simple hydrolytic workup or by filtration through silica gel, rather than by chromatography, as required for Lawesson's reagent.
Thionation of esters and lactones with the reagent combination of phosphorus pentasulfide and hexamethyldisiloxane
Curphey, Thomas J
, p. 371 - 373 (2002)
The combination of P4S10 and hexamethyldisiloxane converts esters and lactones to thionoesters and thionolactones in yields comparable to or superior to those obtained with Lawesson's reagent. The method has the advantage that reagent-derived byproducts may be removed by a simple hydrolytic workup or by filtration through silica gel, rather than by chromatography, as required for Lawesson's reagent.
Nucleophilic Additions to Thionolactones. New Synthetic Technology for the Construction of Medium- and Large-Ring Ethers
Nicolaou, K. C.,McGarry, D. G.,Somers, P. K.,Veale, C. A.,Furst, G. T.
, p. 2504 - 2506 (2007/10/02)
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