1072840-88-0Relevant articles and documents
Cross-coupling reactions of aryl pivalates with boronic acids
Quasdorf, Kyle W.,Tian, Xia,Garg, Neil K.
, p. 14422 - 14423 (2008)
The first cross-coupling of acylated phenol derivatives has been achieved. In the presence of an air-stable Ni(II) complex, readily accessible aryl pivalates participate in the Suzuki-Miyaura coupling with arylboronic acids. The process is tolerant of considerable variation in each of the cross-coupling components. In addition, a one-pot acylation/cross-coupling sequence has been developed. The potential to utilize an aryl pivalate as a directing group has also been demonstrated, along with the ability to sequentially cross-couple an aryl bromide followed by an aryl pivalate, using palladium and nickel catalysis, respectively. Copyright