1072959-67-1 Usage
Description
N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide is a complex organic compound with a unique chemical structure. It is characterized by its potential biological activities and applications in various fields, particularly in the pharmaceutical and chemical industries.
Uses
1. Used in Pharmaceutical Industry:
N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide is used as a potential therapeutic agent for the treatment of Alzheimer's Disease. It functions as an ATP-competitive inhibitor of Rho-kinases (ROCK-I/ROCK-II), which helps in reducing amyloid-β production. By targeting this specific pathway, it is hypothesized that the compound can effectively treat Alzheimer's Disease and delay its further progression.
2. Used in Chemical Research:
In the field of chemical research, N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide serves as a valuable compound for studying its chemical properties, reactivity, and potential applications in the synthesis of other bioactive molecules. Its unique structure allows researchers to explore various synthetic routes and modifications, which could lead to the development of new drugs or materials with improved properties and applications.
Biological Activity
sr-3677 is a novel, potent and highly selective inhibitor of rho kinase (rock-ii) with the ic50 value of ~0.3nm in enzyme and cell based assays [1].sr-3677 has been reported to selectively inhibit the rock- ii with the ic50 values of ~3nm, ~3nm, 56nm, 3.968μm,1.190μm and 7.491μm for rock-ii,ppmlc, rock-i, pka, mrck and akt1, respectively. in addition, sr-3677 has been shown several key binding elements that contribute to the high potency and selectivity in the docking assay. furthermore, sr-3677 has been revealed to be efficacious in enhancing aqueous humor outflow and in target modulation in the pharmacology studies [1].
references
[1] feng y1, yin y, weiser a, griffin e, cameron md, lin l, ruiz c, schürer sc, inoue t, rao pv, schr?ter t, lograsso p. discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective rho kinase (rock-ii) inhibitors. j med chem. 2008 nov 13;51(21):6642-5. doi: 10.1021/jm800986w. epub 2008 oct 4.
Check Digit Verification of cas no
The CAS Registry Mumber 1072959-67-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,7,2,9,5 and 9 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1072959-67:
(9*1)+(8*0)+(7*7)+(6*2)+(5*9)+(4*5)+(3*9)+(2*6)+(1*7)=181
181 % 10 = 1
So 1072959-67-1 is a valid CAS Registry Number.
1072959-67-1Relevant articles and documents
Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors
Feng, Yangbo,Yin, Yan,Weiser, Amiee,Griffin, Evelyn,Cameron, Michael D.,Lin, Li,Ruiz, Claudia,Schürer, Stephan C.,Inoue, Toshihiro,Rao, P. Vasanth,Schr?ter, Thomas,LoGrasso, Philip
supporting information; experimental part, p. 6642 - 6645 (2009/10/23)
The identification of a new class of potent and selective ROCK-II inhibitors is presented. Compound 5 (SR-3677) had an IC50 of ~3 nM in enzyme and cell based assays and had an off-target hit rate of 1.4% against 353 kinases, and inhibited only 3 out of 70 nonkinase enzymes and receptors. Pharmacology studies showed that 5 was efficacious in both, increasing ex vivo aqueous humor outflow in porcine eyes and inhibiting myosin light chain phosphorylation.