1073486-93-7

Basic information

• Product Name: 2,3-diphenyl-4-carboxylic acid ethyl ester-isoquinolin-1(2H)-one
• Synonyms: 2,3-diphenyl-4-carboxylic acid ethyl ester-isoquinolin-1(2H)-one
• CAS NO: 1073486-93-7
• Molecular Weight: 369.42
• Mol File: 1073486-93-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2,3-diphenyl-4-carboxylic acid ethyl ester-isoquinolin-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-diphenyl-4-carboxylic acid ethyl ester-isoquinolin-1(2H)-one(1073486-93-7)
• EPA Substance Registry System: 2,3-diphenyl-4-carboxylic acid ethyl ester-isoquinolin-1(2H)-one(1073486-93-7)

Safety Data

• Hazardous Substances Data: 1073486-93-7(Hazardous Substances Data)

Upstream product

• 1747-80-4 2-fluoro-N-phenylbenzamide 
• 2216-94-6 phenylpropynoic acid ethyl ester 
• 62-53-3 aniline 
• 23564-81-0 N-phenyl-2-(2-chlorophenyl)formamidine 
• 873-32-5 2-Chlorobenzonitrile 
• 201230-82-2 carbon monoxide 
• 128823-22-3 (2-iodophenyl)propanedioic acid diethyl ester 
• 4903-36-0 N-phenyl-benzimidoyl chloride 

Relevant articles and documents

Nickel-Catalyzed Annulation of o-Haloarylamidines with Aryl Acetylenes: Synthesis of Isoquinolone and 1-Aminoisoquinoline Derivatives

An efficient method for the synthesis of substituted 1(2H)-isoquinolone derivatives via nickel-catalyzed annulation of substituted 2-halobenzamidines with aryl alkynes in the presence of water is described. Benzo[4,5]imidazo[2,1-a]isoquinolines were formed as the dominated products when dry dimethyl sulfoxide was used as the solvent. Furthermore, when benzyl substituted amidines were used as the substrates, debenzylation reaction occured to provide various 1-aminoisoquinoline products. (Figure presented.).

Palladium-catalyzed carbonylation-decarboxylation of diethyl(2-iodoaryl) malonates with imidoyl chlorides: An efficient route to substituted isoquinolin-1(2H)-ones

(Chemical Equation Presented) A wide variety of substituted isoquinolin-1(2H)-ones were synthesized in reasonable to good yields by the palladium-catalyzed cyclization of diethyl(2-iodoaryl)malonates with imidoyl chlorides and carbon monoxide in tetrahydrofuran. A palladium-catalyzed carbonylation-decarboxylation process may be involved in the one-step synthesis of the isoquinolin-1(2H)-ones.