107351-59-7Relevant articles and documents
Micromolecular non-nucleoside compound as immunomodulator
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Paragraph 0157-0160, (2021/06/09)
The invention discloses a structure, a preparation method and application of a micromolecular non-nucleoside targeted CD73 immunomodulator. The structure of the compound is shown as a general formula (I), and R1, R2, R3, R4, R5, X, Y and W groups are defined as in the claims. The compound acts on CD73 protein, blocks the interaction between the CD73 protein and a substrate of the CD73 protein, and can be used for preparing medicines and/or compositions for treating and/or diagnosing cancers, infectious diseases, autoimmune diseases and neurodegenerative diseases.
Substituted benzene and heterocyclic compound and its preparation method and application
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Paragraph 0393; 0394; 0395, (2016/10/20)
The invention provides substituted benzoheterocyclic compounds and a preparation method thereof. The compounds have structures shown by formulas I and II. The invention also provides the effects of the compounds shown by formulas I and II in resisting virus, tumor and the like. The invention further provides a medicine composition taking the compounds shown by the formulas I and II as active ingredients, and the anti-virus or anti-tumor effect of the medicine composition. The invention lays a foundation for the future in-depth study and development of the anti-virus or anti-tumor medicine of the compounds.
SYNTHESIS OF THE BACTERIAL COENZYME METHOXATIN
MacKenzie, A. Roderick,Moody, Christopher J.,Rees, Charles W.
, p. 3259 - 3268 (2007/10/02)
A short total synthesis of the bacterial coenzyme methoxatin (1) (4,5-dihydro-4,5-dioxo-1H-pyrroloquinoline-2,7,9-tricarboxylic acid) is described.The route involves the two step conversion of 4-acetamido-2-benzyloxybenzaldehyde (5b) into methyl 6-acetamido-4-benzyloxyindole-2-carboxylate (7b) (74percent), followed by regioselective annulation of the third ring (55percent), and debenzylation and oxidation with benzoyl t-butyl nitroxide to give the tricyclic quinone triester (13) (methoxatin triester) (83percent).