1073520-81-6Relevant articles and documents
A convenient synthesis of 2β,3α-dihydroxyurs-12-en-28-oic acid as a natural diastereoisomer of corosolic acid
Wang, Shi-Sheng,Luo, Li-Juan,Gao, Zhi-Gang,Guan, Tong-Wei,Zhao, Wei-Jie
, p. 617 - 618 (2013/07/27)
2β,3α-Dihydroxyurs-12-en-28-oic acid (6) is a naturally occurring diastereoisomer of corosolic acid with glycogen phosphorylase inhibitory activity. A new strategy for the semi-synthesis of 6 was developed. Using the commercially available ursolic acid (1) as the starting materials, 6 was synthesized through five facile reactions with a high stereoselectivity and an overall yield of 47.3%. The structure of 6 was confirmed by optical rotation, ESI-MS, 1H NMR and 13C NMR data.