107377-07-1

Basic information

• Product Name: 4-N-BUTYLBENZAMIDE
• Synonyms: 4-N-BUTYLBENZAMIDE;4-BUTYLBENZAMIDE;4-BUTYLAMINOMETHYL-PHENYLAMINE
• CAS NO: 107377-07-1
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.24
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 107377-07-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 127 °C
• Boiling Point: 309.9 °C at 760 mmHg
• Flash Point: 141.2 °C
• Appearance: /
• Density: 1.018 g/cm³
• Vapor Pressure: 0.000622mmHg at 25°C
• Refractive Index: 1.533
• PKA: 16.20±0.50(Predicted)
• CAS DataBase Reference: 4-N-BUTYLBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-N-BUTYLBENZAMIDE(107377-07-1)
• EPA Substance Registry System: 4-N-BUTYLBENZAMIDE(107377-07-1)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-37
• Hazardous Substances Data: 107377-07-1(Hazardous Substances Data)

Usage

General Description

4-N-butylbenzamide is a chemical compound with the molecular formula C11H15NO. It is a derivative of benzamide, with a butyl group attached to the nitrogen atom. 4-N-BUTYLBENZAMIDE is commonly used in research and industrial applications as a building block for the synthesis of other organic compounds. It has also been studied for its potential pharmaceutical properties, including its ability to interact with receptors in the central nervous system. 4-N-butylbenzamide is typically produced through organic synthesis methods and is a white to off-white crystalline solid at room temperature.

InChI:InChI=1/C11H15NO/c1-2-3-4-9-5-7-10(8-6-9)11(12)13/h5-8H,2-4H2,1H3,(H2,12,13)

Upstream product

• 28788-62-7 4-butylbenzoyl chloride 
• 20651-71-2 4-butyl benzoic acid 
• 1336-21-6 ammonium hydroxide 
• 37920-25-5 1-(4-butylphenyl)ethanone 
• 15226-74-1 dicobalt octacarbonyl 
• 41492-05-1 p-bromobutylbenzene 
• 79887-09-5 (4-butylphenyl)acetylene 

Downstream Products

• 57802-79-6 4-n-butylbenzylamine 
• 1208077-46-6 4-n-butylthiobenzamide 
• 1313711-81-7 1-(2-(4-butylphenyl)-4-methylthiazol-5-yl)ethanone 
• 1313711-82-8 2-(1-(2-(4-butylphenyl)-4-methylthiazol-5-yl)ethylidene)hydrazinecarboximidamide 
• 60834-63-1 p-butylbenzyl alcohol 
• 113932-84-6 methyl (4-butylphenyl)carbamate 

Relevant articles and documents

Copper-catalyzed aerobic oxidative C-C bond cleavage for C-N bond formation: From ketones to amides

A novel copper-catalyzed aerobic oxidative C(CO)-C(alkyl) bond cleavage reaction of aryl alkyl ketones for C-N bond formation is described. A series of acetophenone derivatives as well as more challenging aryl ketones with long-chain alkyl substituents could be selectively cleaved and converted into the corresponding amides, which are frequently found in biologically active compounds and pharmaceuticals.

Visible Light-Induced Iodine-Catalyzed Transformation of Terminal Alkynes to Primary Amides via C≡C Bond Cleavage under Aqueous Conditions

The visible light-induced iodine-catalyzed oxidative cleavage of the C≡C bond for transforming terminal alkynes into primary amides in the presence of ammonia under aqueous conditions is described. This metal-free protocol which ensued via initial hydroamination of the acetylene bond followed by liberation of diiodomethane (CH2I2) was found to be applicable to aromatic, heteroaromatic and aliphatic alkynes.

Discovery and characterization of potent thiazoles versus methicillin- and vancomycin-resistant Staphylococcus aureus

Methicillin- and vancomycin-resistant Staphylococcus aureus (MRSA and VRSA) infections are growing global health concerns. Structure-activity relationships of phenylthiazoles as a new antimicrobial class have been addressed. We present 10 thiazole derivatives that exhibit strong activity against 18 clinical strains of MRSA and VRSA with acceptable PK profile. Three derivatives revealed an advantage over vancomycin by rapidly eliminating MRSA growth within 6 h, and no derivatives are toxic to HeLa cells at 11 μg/mL.