1074-91-5 Usage
Description
1-Bromo-2,3,4,5-tetrafluorobenzene is an organic compound characterized by its bromine atom and four fluorine atoms attached to a benzene ring. It is a halogenated aromatic compound known for its unique chemical properties and reactivity, making it a valuable intermediate in various chemical syntheses.
Uses
1. Used in Organic Synthesis:
1-Bromo-2,3,4,5-tetrafluorobenzene is used as a research chemical for organic synthesis due to its unique structure and reactivity. Its bromine and fluorine atoms can participate in various chemical reactions, such as substitution, addition, and elimination, facilitating the formation of a wide range of compounds.
2. Used in Catalyst Synthesis:
In the field of catalysis, 1-Bromo-2,3,4,5-tetrafluorobenzene is used in the synthesis of the catalyst Pd(AsPh3)4. This catalyst is essential for the preparation of cyclometalating ligands, such as 2-(3′,4′,6′-trifluorophenyl)pyridine (n=4) and 2-(3′,4′,5′,6′-tetrafluorophenyl)pyridine. These ligands are crucial components in the development of new catalysts and materials with specific properties and applications.
3. Used in Fluorinated Rubrene Synthesis:
1-Bromo-2,3,4,5-tetrafluorobenzene may also be utilized in the synthesis of fluorinated rubrene, a derivative of the organic semiconductor rubrene. Fluorinated rubrene exhibits improved electronic properties compared to its non-fluorinated counterpart, making it a promising material for applications in organic electronics, such as organic light-emitting diodes (OLEDs) and organic field-effect transistors (OFETs).
Check Digit Verification of cas no
The CAS Registry Mumber 1074-91-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,7 and 4 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1074-91:
(6*1)+(5*0)+(4*7)+(3*4)+(2*9)+(1*1)=65
65 % 10 = 5
So 1074-91-5 is a valid CAS Registry Number.
InChI:InChI=1/C6HBrF4/c7-2-1-3(8)5(10)6(11)4(2)9/h1H
1074-91-5Relevant articles and documents
Synthesis and antimycobacterial evaluation of newer 1-cyclopropyl-1,4-dihydro-6-fluoro-7-(substituted secondary amino)-8-methoxy-5-(sub)-4-oxoquinoline-3-carboxylic acids
Senthilkumar, Palaniappan,Dinakaran, Murugesan,Banerjee, Debjani,Devakaram, Ruth Vandana,Yogeeswari, Perumal,China, Arnab,Nagaraja, Valakunja,Sriram, Dharmarajan
, p. 2558 - 2569 (2008/09/21)
Thirty-four newer 1-cyclopropyl-1,4-dihydro-6-fluoro-7-(substituted secondary amino)-8-methoxy-5-(sub)-4-oxoquinoline-3-carboxylic acids were synthesized from 1,2,3,4-tetrafluoro benzene and evaluated for in vitro and in vivo antimycobacterial activities against Mycobacterium tuberculosis H37Rv (MTB), multi-drug resistant M. tuberculosis (MDR-TB) and Mycobacterium smegmatis (MC2) and also tested for the ability to inhibit the supercoiling activity of DNA gyrase. Among the synthesized compounds, 7-(1-(4-methoxybenzyl)-3,4,5,6,7,8-hexahydroisoquinolin-2(1H)-yl)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-5-nitro-4-oxoquinoline-3-carboxylic acid (13n) was found to be the most active compound in vitro with MIC of 0.16 and 0.33 μM against MTB and MDR-TB, respectively. In the in vivo animal model 13n decreased the bacterial load in lung and spleen tissues with 2.54 and 2.92 - log10 protections, respectively, at the dose of 50 mg/kg body weight. Compound 13n also inhibited the supercoiling activity of mycobacterial DNA gyrase with IC50 of 30.0 μg/ml.
Process for the preparation of tetrafluorohalogenbenzenes
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, (2008/06/13)
A process is described for the preparation of compounds having the formula (I) C6F4HX, wherein X is Br or Cl, which comprises reacting tetrafluorobenzene with a halogen in the presence of a Lewis acid catalyst.
