107456-42-8

Basic information

• Product Name: 1-(4-chlorobenzyl)-1H-benzo[d]imidazole
• Synonyms: 1-(4-chlorobenzyl)-1H-benzo[d]imidazole
• CAS NO: 107456-42-8
• Molecular Weight: 242.708
• Mol File: 107456-42-8.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 1-(4-chlorobenzyl)-1H-benzo[d]imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-chlorobenzyl)-1H-benzo[d]imidazole(107456-42-8)
• EPA Substance Registry System: 1-(4-chlorobenzyl)-1H-benzo[d]imidazole(107456-42-8)

Safety Data

• Hazardous Substances Data: 107456-42-8(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 5729-18-0 N-(p-Chlorophenylmethyl)-2-amino aniline 
• 64-18-6 formic acid 
• 51-17-2 benzoimidazole 
• 622-95-7 4-chlorobenzyl bromide 
• 106-43-4 para-chlorotoluene 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 53746-69-3 N,N-Dimethyl-N'-2-bromphenylformamidin 
• 104-86-9 4-chlorobenzylamine 
• 615-36-1 2-bromoaniline 
• 67-56-1 methanol 
• 5822-16-2 N-(p-Chlorobenzyl)-2-nitro aniline 
• 1493-27-2 ortho-nitrofluorobenzene 

Downstream Products

• 1569410-45-2 dichloro-(N-(4-chlorobenzyl)benzimidazole)(p-cymene)ruthenium 
• 149122-76-9 1,3-bis(4-chlorobenzyl)benzimidazolium chloride 
• 1394047-28-9 C₂₅H₂₂ClN₇OS 
• 537010-34-7 1-(4-chlorobenzyl)-1H-benzo[d]imidazole-2-carbaldehyde 
• 1298093-94-3 1-(4-chlorobenzyl)-3-[2-(morpholinium-N-yl)ethyl]benzimidazolium dichloride 
• 1298093-86-3 1-(4-chlorobenzyl)-3-[2-(piperidinium-1-yl)ethyl]benzimidazolium dichloride 

Relevant articles and documents

CO-releasing properties and anticancer activities of manganese complexes with imidazole/benzimidazole ligands

Carbon monoxide (CO) is an important signaling molecule which plays significant roles in the pathogenesis of cancer. CO is produced by enzymatic degradation of heme in mammals. Heme oxygenase 1 (HO-1) catalyzes the breakdown of heme into CO, ferrous iron, and biliverdin. CO induces HO-1 and inhibits cell proliferation. Cancer cells exposed to several stress factors (hypoxia, reactive oxygen species, cis-platin, and oxidative stress), and HO-1 displays cytoprotective role against oxidative stress and inhibits apoptosis, metastases, angiogenesis, and cell proliferation processes. Therefore, metal containing CO-releasing molecules (CORMs) have been designed as an effective cancer treatment strategy. CORMs are responsible for releasing controlled amounts of CO to cells and tissues. Thus, we synthesized [Mn(CO)3(bpy)L]X manganese containing CORMs [bpy?=?2,2′-bipyridine, X?=?hexafluorophosphate (PF6), trifluoromethanesulfonate (OTf), L?=?imidazole, methylimidazole, benzimidazole, N-benzylbenzimidazole, N-(4-chlorobenzyl)benzimidazole] to release CO in human invasive ductal breast (MCF-7) cell line. In vitro experiments indicated that the compounds inhibited cell proliferation and exhibited cytotoxic effect on breast cancer cells. Moreover, side groups of the compounds enhanced the anticancer effects in MCF-7 cell line. These manganese containing CORMs gave promising results and may be used as a drug template for effective treatment of invasive ductal breast carcinoma.

Methanol as the C1source: Redox coupling of nitrobenzenes and alcohols for the synthesis of benzimidazoles

We present an operationally simple redox coupling for the synthesis of N-1 substituted benzimidazoles using feedstock building block 2-nitroaniline derivatives as the precursors and methanol as the C1 source. Higher atom, step, and redox economies and exc

Benzimidazolium salts prevent and disrupt methicillin-resistant: Staphylococcus aureus biofilms

Emergence of resistant bacteria encourages us to develop new antibiotics and strategies to compensate for the different mechanisms of resistance they acquire. One of the defense mechanisms of resistant bacteria is the formation of biofilms. Herein we show