107496-45-7Relevant articles and documents
Synthesis of Fluorine-Containing Peptides. Analogues of Angiotensin II Containing Hexafluorovaline.
Vine, William H.,Hsieh, Kun-hwa,Marshall, Garland R.
, p. 1043 - 1047 (1981)
γ,γ,γ,γ',γ',γ'-Hexafluorovaline and derivatives have been prepared and incorporated into angiotensin II by fragment condensation and solid-phase peptide synthesis.Hexafluorovaline derivatives showed general resistance toward various enzymatic digestions and the tendency to racemize extensively upon carboxyl activation.When the angiotensin II analogues were assayed on rat uterus, 5>AII had 133percent activity, 5>AII was inactive, and 1,DL-Hfv8>AII was a potent inhibitor of angiotensin II in vitro and in vivo.