1075240-43-5 Usage
General Description
OMadacycline (tosylate) is a novel tetracycline antibiotic that is used to treat a variety of bacterial infections. It works by inhibiting protein synthesis in bacterial cells, ultimately leading to their death. OMadacycline is active against a wide range of bacteria, including both Gram-positive and Gram-negative organisms, making it a versatile treatment option. It is also effective against drug-resistant strains of bacteria, making it an important tool in the fight against antibiotic resistance. OMadacycline is often well-tolerated with a favorable safety profile, making it a valuable option for patients with various infections.
Check Digit Verification of cas no
The CAS Registry Mumber 1075240-43-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,7,5,2,4 and 0 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1075240-43:
(9*1)+(8*0)+(7*7)+(6*5)+(5*2)+(4*4)+(3*0)+(2*4)+(1*3)=125
125 % 10 = 5
So 1075240-43-5 is a valid CAS Registry Number.
1075240-43-5Relevant articles and documents
Synthesis development of an aminomethylcycline antibiotic via an electronically tuned acyliminium Friedel-Crafts reaction
Chung, John Y.L.,Hartner, Frederick W.,Cvetovich, Raymond J.
body text, p. 6095 - 6100 (2009/04/05)
With the goal of improving the synthetic efficiency, the development of a convergent synthesis of a minocycline derivative PTK0796 via an intermolecular acyliminium Friedel-Crafts reaction (Tscherniac-Einhorn reaction) is described. The entire C9 neopentylaminomethyl side chain was installed in one step using an electronically optimized chloromethylacyliminium precursor in 83% yield. Deprotection and re-equilibration to the C4 α-epimer in the presence of CaCl2 and ethanolamine or NaOH afforded the target aminomethylcycline antibiotic. The corresponding crystalline tosylate salt was found to exhibit improved solid state stability.