107558-16-7

Basic information

• Product Name: Ethanone, 1-[4-[(4-nitrophenyl)thio]phenyl]-
• CAS NO: 107558-16-7
• Molecular Formula: C14H11NO3S
• Molecular Weight: 273.312
• Mol File: 107558-16-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-[4-[(4-nitrophenyl)thio]phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-[4-[(4-nitrophenyl)thio]phenyl]-(107558-16-7)
• EPA Substance Registry System: Ethanone, 1-[4-[(4-nitrophenyl)thio]phenyl]-(107558-16-7)

Safety Data

• Hazardous Substances Data: 107558-16-7(Hazardous Substances Data)

Upstream product

• 952-97-6 4-nitrophenyl phenyl sulfide 
• 108-24-7 acetic anhydride 
• 24067-17-2 4-nitrophenylboronic acid 
• 99-93-4 4-Hydroxyacetophenone 
• 64101-67-3 4-acetylphenyl p-toluenesulfonate 
• 13031-43-1 4-acetyloxyacetophenone 
• 1849-36-1 para-nitrobenzenethiol 
• 149104-90-5 4-acetylphenylboronic acid 
• 75-36-5 acetyl chloride 
• 7637-07-2 boron trifluoride 
• 73408-22-7 4-(4-nitro-phenylsulfanyl)-benzoyl chloride 
• 506-82-1 dimethylcadmium 
• 32676-68-9 mixed anhydride of acetic and trichloroacetic acids 
• 506-96-7 Acetyl bromide 

Downstream Products

• 107920-30-9 C₁₄H₁₂N₂O₃S 
• 101284-40-6 acetic acid-[4-(4-acetyl-benzenesulfonyl)-anilide] 
• 101283-64-1 acetic acid-[4-(4-acetyl-phenylsulfanyl)-anilide] 
• 100710-53-0 1-[4-(4-amino-phenylsulfanyl)-phenyl]-ethanol 
• 114617-14-0 N-[4-(4-acetyl-phenylsulfanyl)-phenyl]-diacetamide 
• 101533-62-4 1-[4-(4-nitro-benzenesulfonyl)-phenyl]-ethanone 
• 14453-89-5 1-(4-((4-aminophenyl)thio)phenyl)ethan-1-one 
• 117881-01-3 bis-[4-(4-acetyl-phenylsulfanyl)-phenyl]-diazene-N-oxide 

Relevant articles and documents

Direct C-S bond formation: Via C-O bond activation of phenols in a crossover Pd/Cu dual-metal catalysis system

A dual-metal catalysis system including a newly prepared nanoparticle [SiO2@organic-linker(OL)@Pd(II)] and CuI was introduced with ultra-high catalytic activity (high turnover number (TON), up to 19000) to a one-pot and odorless synthesis of unsymmetrical aryl sulfides by crossover C-S bond formation. The reaction proceeds via C-O bond activation of phenols and direct C-S bond formation in the presence of S8 as an oddorless sulfur source and aryl boronic acids under mild conditions (room temperature). The catalyst could be recycled up to five times without an obvious change in its activity.

Copper mediated formation of carbon-heteroatom bonds using organoboron reagents and ultrasound

This report summarizes research efforts focused on copper acetate mediated reactions to form new carbon-heteroatom bonds using organoboron reagents under ultrasound irradiation. The method involves the application of ultrasound irradiation to the Chan-Evans-Lam reaction to achieve O-arylation of phenols, N-arylation of anilines and indoles, and S-arylation of thiols. Ultrasound irradiation was found to decrease reaction times from 72 hours to 4 hours while improving the product yields an average of 20%.1 Representative C-O, C-N, and C-S coupling reactions were successfully scaled-up from the milligram to gram levels while maintaining good product yields offering potential applications in industrial processes.

The synthesis and SAR of novel diarylsulfone 11β-HSD1 inhibitors

In this communication, human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitory activities of a novel series of diarylsulfones are described. Optimization of this series resulted in several highly potent 11β-HSD1 inhibitors with excellent pharmacokinetic (PK) properties. Compound (S)-25 showed excellent efficacy in a non-human primate ex vivo pharmacodynamic model.