1075719-57-1

Basic information

• Product Name: 6-{4-[(2-(4-acetylamino-benzoylamino)-phenylcarbamoyl)oxymethyl]-2-nitro-phenoxy}-tetrahydro-2H-pyran-2-carboxylic acid
• Synonyms: 6-{4-[(2-(4-acetylamino-benzoylamino)-phenylcarbamoyl)oxymethyl]-2-nitro-phenoxy}-tetrahydro-2H-pyran-2-carboxylic acid
• CAS NO: 1075719-57-1
• Molecular Weight: 640.56
• Mol File: 1075719-57-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-{4-[(2-(4-acetylamino-benzoylamino)-phenylcarbamoyl)oxymethyl]-2-nitro-phenoxy}-tetrahydro-2H-pyran-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-{4-[(2-(4-acetylamino-benzoylamino)-phenylcarbamoyl)oxymethyl]-2-nitro-phenoxy}-tetrahydro-2H-pyran-2-carboxylic acid(1075719-57-1)
• EPA Substance Registry System: 6-{4-[(2-(4-acetylamino-benzoylamino)-phenylcarbamoyl)oxymethyl]-2-nitro-phenoxy}-tetrahydro-2H-pyran-2-carboxylic acid(1075719-57-1)

Safety Data

• Hazardous Substances Data: 1075719-57-1(Hazardous Substances Data)

Upstream product

• 1075719-61-7 6-{4-[(2-(4-acetylamino-benzoylamino)-phenylcarbamoyl)oxymethyl]-2-nitro-phenoxy}-tetrahydro-2H-pyran-2-carboxylic acid methyl ester 

Downstream Products

• 489-91-8 D-glucuronic acid 
• 124-38-9 carbon dioxide 
• 41833-13-0 4-hydroxymethyl-2-nitrophenol 
• 112522-64-2 CI-994 

Relevant articles and documents

Synthesis and biological evaluation of glucuronide prodrugs of the histone deacetylase inhibitor CI-994 for application in selective cancer chemotherapy

Two glucuronide prodrugs of the histone deacetylase inhibitor CI-994 were synthesized. These compounds were found to be soluble in aqueous media and stable under physiological conditions. The carbamoyl derivatisation of CI-994 significantly decreased its toxicity towards NCI-H661 lung cancer cells. Prodrug incubation with β-glucuronidase in the culture media led efficiently to the release of the parent drug and thereby restoring its ability to decrease cell proliferation, to inhibit HDAC and to induce E-Cadherin expression.