1076689-36-5

Basic information

• Product Name: 4-chloro-6-(3,5-difluorophenylamino)-2-methylsulfanylpyrimidine-5-carbonitrile
• Synonyms: 4-chloro-6-(3,5-difluorophenylamino)-2-methylsulfanylpyrimidine-5-carbonitrile
• CAS NO: 1076689-36-5
• Molecular Weight: 312.73
• Mol File: 1076689-36-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-chloro-6-(3,5-difluorophenylamino)-2-methylsulfanylpyrimidine-5-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-6-(3,5-difluorophenylamino)-2-methylsulfanylpyrimidine-5-carbonitrile(1076689-36-5)
• EPA Substance Registry System: 4-chloro-6-(3,5-difluorophenylamino)-2-methylsulfanylpyrimidine-5-carbonitrile(1076689-36-5)

Safety Data

• Hazardous Substances Data: 1076689-36-5(Hazardous Substances Data)

Upstream product

• 372-39-4 3,5-difluoroaniline 
• 33097-13-1 4,6-dichloro-2-(methylthio)-5-pyrimidinecarbonitrile 

Downstream Products

• 1076689-38-7 C₁₂H₉F₂N₅S 

Relevant articles and documents

Structure-activity relationship studies of imidazo[1,2-c]pyrimidine derivatives as potent and orally effective Syk family kinases inhibitors

Spleen tyrosine kinase (Syk) and zeta-associated protein kinase of 70 kDa (ZAP-70) are members of the Syk family and non-receptor-type protein tyrosine kinases, which play crucial roles in B- and T-cell activation. Therefore, a Syk family tyrosine kinases inhibitor would be a useful therapeutic agent for the treatment of various allergic disorders and autoimmune diseases. Previously, we reported that 1,2,4-triazolo[4,3-c]pyrimidine derivative 1 and 1,2,4-triazolo[1,5-c]pyrimidine derivative 2 showed strong inhibitory activities against Syk family kinases. These compounds also exhibited high-level suppression of IL-2 in cellular assays. However, their oral efficacies were poor in a mouse model of IL-2 production. To improve oral effectiveness, we investigated a new series of Syk family kinases inhibitors. We found that imidazo[1,2-c]pyrimidine derivatives potently inhibited the Syk family kinases. Among these agents, compound 9f not only showed strong inhibitory activities against Syk and ZAP-70 kinases in vitro, but its oral administration resulted in the in vivo suppression of both the passive cutaneous anaphylaxis reaction and Concanavalin A-induced IL-2 production in a mouse model.