107697-82-5

Basic information

• Product Name: Pyrazine, phenoxy-
• CAS NO: 107697-82-5
• Molecular Formula: C10H8N2O
• Molecular Weight: 172.186
• Mol File: 107697-82-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Pyrazine, phenoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrazine, phenoxy-(107697-82-5)
• EPA Substance Registry System: Pyrazine, phenoxy-(107697-82-5)

Safety Data

• Hazardous Substances Data: 107697-82-5(Hazardous Substances Data)

Upstream product

• 14508-49-7 2-chloropyrazin 
• 139-02-6 sodium phenoxide 
• 184592-91-4 2-pyrazinecarboxylic acid phenyl ester 
• 108-95-2 phenol 

Downstream Products

• 1372607-38-9 1-phenoxycarbonyl-3-phenoxy-1,2-dihydropyrazine 

Relevant articles and documents

Efficient nucleophilic substitution reactions of pyrimidyl and pyrazyl halides with nucleophiles under focused microwave irradiation

Rapid nucleophilic displacement reactions of 2-chloropyrimidine, 2-bromopyrimidine, 5-bromopyrimidine and chloropyrazine with nucleophiles under microwave irradiation was complete within several minutes with yields up to 99%. The method using microwave irradiation is superior to the classical heating processes.

Decarbonylative Diaryl Ether Synthesis by Pd and Ni Catalysis

Because diaryl ethers are present as an important motif in pharmaceuticals and natural products, extensive studies for the development of novel methods have been conducted. A conventional method for the construction of the diaryl ether moiety is the intermolecular cross-coupling reaction of aryl halides and phenols with a copper or palladium catalyst. We developed a catalytic decarbonylative etherification of aromatic esters using a palladium or nickel catalyst with our enabling diphosphine ligand to give the corresponding diaryl ethers. The present reaction can be conducted on gram scale in excellent yield. This reaction not only functions in an intramolecular setting but also allows for a cross-etherification using other phenols.

Keratinocyte growth inhibitors and hydroxamic acid derivatives

This invention relates to a keratinocyte-proliferation inhibitor comprising as active ingredient a compound having an activity of inhibiting the solubilization of heparin-binding EGF-like growth factor bound to cell membranes and a compound of the formula (I); or pharmaceutically acceptable salt thereof, wherein R1, R2, R3 are hydrogen atom or alkyl and X is substituted benzene or the like.