107717-52-2

Basic information

• Product Name: 2-(benzyloxy)-6,7-dimethoxy-4H-3,1-benzoxazin-4-one
• Synonyms: 2-(benzyloxy)-6,7-dimethoxy-4H-3,1-benzoxazin-4-one
• CAS NO: 107717-52-2
• Molecular Weight: 313.31
• Mol File: 107717-52-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(benzyloxy)-6,7-dimethoxy-4H-3,1-benzoxazin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(benzyloxy)-6,7-dimethoxy-4H-3,1-benzoxazin-4-one(107717-52-2)
• EPA Substance Registry System: 2-(benzyloxy)-6,7-dimethoxy-4H-3,1-benzoxazin-4-one(107717-52-2)

Safety Data

• Hazardous Substances Data: 107717-52-2(Hazardous Substances Data)

Upstream product

• 5653-40-7 2-Amino-4,5-dimethoxybenzoic acid 
• 39608-52-1 benzyl carbonochloridate 
• 501-53-1 benzyl chloroformate 
• 126194-06-7 2-benzyloxycarbonylamino-4,5-dimethoxybenzoic acid 

Relevant articles and documents

Benzoxazin-4-ones as novel, easily accessible inhibitors for rhomboid proteases

Rhomboid proteases form one of the most widespread intramembrane protease families. They have been implicated in variety of human diseases. The currently reported rhomboid inhibitors display some selectivity, but their construction involves multistep synthesis protocols. Here, we report benzoxazin-4-ones as novel inhibitors of rhomboid proteases with a covalent, but slow reversible inhibition mechanism. Benzoxazin-4-ones can be synthesized from anthranilic acid derivatives in a one-step synthesis, making them easily accessible. We demonstrate that an alkoxy substituent at the 2-position is crucial for potency and results in low micromolar inhibitors of rhomboid proteases. Hence, we expect that these compounds will allow rapid synthesis and optimization of inhibitors of rhomboids from different organisms.

Single-step preparation of 2-alkoxy(phenoxy)-4H-3,1-benzoxazine-4-ones inhibiting chymotrypsin

-