107864-71-1

Basic information

• Product Name: 1,3,5-tris(azidomethyl)benzene
• Synonyms: 1,3,5-tris(azidomethyl)benzene
• CAS NO: 107864-71-1
• Molecular Weight: 243.231
• Mol File: 107864-71-1.mol
• Article Data: 28

Chemical Properties

• CAS DataBase Reference: 1,3,5-tris(azidomethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,5-tris(azidomethyl)benzene(107864-71-1)
• EPA Substance Registry System: 1,3,5-tris(azidomethyl)benzene(107864-71-1)

Safety Data

• Hazardous Substances Data: 107864-71-1(Hazardous Substances Data)

Upstream product

• 18226-42-1 1,3,5-Tris(bromomethyl)benzene 
• 108-67-8 1,3,5-trimethyl-benzene 
• 2672-58-4 1,3,5-tris-(methoxycarbonyl)benzene 
• 554-95-0 benzene-1,3,5-tricarboxylic acid 
• 4464-18-0 1,3,5-tris(hydroxymethyl)benzene 

Downstream Products

• 1233382-79-0 C₅₁H₆₃N₁₅O₃ 
• 1233382-81-4 C₅₁H₅₇N₁₅O₃ 
• 1233382-82-5 C₅₄H₆₃N₁₅O₃ 
• 1233382-83-6 C₅₁H₅₇N₁₅O₆ 
• 1233382-85-8 C₅₇H₆₉N₁₅O₃ 
• 1233382-88-1 C₆₀H₇₅N₁₅O₃ 
• 1233382-91-6 C₅₇H₆₉N₁₅O₆ 
• 1233382-96-1 C₄₂H₃₆N₁₂O₃ 
• 1393596-49-0 C₉₃H₉₉N₁₅O₂₁ 
• 1393596-50-3 C₉₃H₉₉N₁₅O₁₈ 
• 1393596-51-4 C₈₄H₁₀₅N₁₅O₂₁ 

Relevant articles and documents

A new selective turn-on fluorogenic dipodal-cobalt(II) ensemble probe for nitrite ion detection and live cell imaging

A new dipodal-triazole-Co2+-ensemble with a ligand containing quinoline moiety was designed and synthesized as a highly sensitive fluorescent sensor for nitrite in aqueous media. Based on in situ-formed Co2+-DTQ (Co2+ chelated dipodal of triazole-quinoline) ensembles having the specific binding affinity for nitrite anions over other anions, this sensory system allows rapid recognition and quantitative detection of nitrite in neutral aqueous media in an 'off-on' fashion. To confirm the suitability of DTQ for biological applications, we also employed it for the fluorescence detection of the changes of intracellular NO2- in three different species of cultured cells in the presence of nitrite ions.

Synthesis, spectroscopic and theoretical studies of new quasi-podands from bile acid derivatives linked by 1,2,3-triazole rings

A novel method for the synthesis of bile acid derivatives has been developed using "click chemistry". Intermolecular 1,3-dipolar cycloaddition of the propargyl ester of bile acids and azide groups of 1,3,5-tris(azidomethyl)benzene gave a new quasi-podands

Formation of Supramolecular Polymers from Porphyrin Tripods

A porphyrin tripod (PZnT) composed of three zinc porphyrin wings connected via triazole bridges was prepared as a monomeric building block for a supramolecular polymer. PZnT formed long fibrous supramolecular polymers with a diameter of 7 nm through the axial coordination of triazole nitrogen atoms to zinc porphyrins. The molecular packing structure of a PZnT-based supramolecular polymer was assigned as a hexagonal columnar phase. PZnT formed a stable 1:1 host-guest complex with 1,3,5-tris(4-pyridyl)benzene (Py3B) through axial coordination of pyridyl groups to zinc porphyrins. The host-guest complex between PZnT and Py3B adopts a cone-shaped geometry. After the addition of Py3B, the host-guest complex exhibited a characteristic X-ray diffraction pattern of rectangular columnar ordering. Furthermore, the formation of supercoiled helical fibrous assemblies was observed by transmission electron microscopy (TEM).

Design and Synthesis of Oleanolic Acid Trimers to Enhance Inhibition of Influenza Virus Entry

Influenza is a major threat to millions of people worldwide. Entry inhibitors are of particular interest for the development of novel therapeutic strategies for influenza. We have previously discovered oleanolic acid (OA) to be a mild influenza hemagglutinin (HA) inhibitor. In this work, inspired by the 3D structure of HA as a homotrimeric receptor, we designed and synthesized 15 OA trimers with different linkers and central region via the copper-catalyzed azide-alkyne cycloaddition reaction. All of the OA trimers were evaluated for their antiviral activities in vitro, and 12c, 12e, 13c, and 13d were observed to exhibit robust potency (IC50 in the submicromolar range) against influenza A/WSN/33 (H1N1) virus that was stronger than that observed with oseltamivir. In addition, these compounds also displayed strong biological activity against A/Hong Kong/4801/2014 and B/Sichuan/531/2018 (BV). The results of hemagglutination inhibition assays and surface plasmon resonance binding assays suggest that these OA trimers may interrupt the interaction between the HA protein of influenza virus and the host cell sialic acid receptor, thus blocking viral entry. These findings highlight the utility of multivalent OA conjugates to enhance the ligand-target interactions in anti-influenza virus drug design and are also helpful for studying antiviral drugs derived from natural products.

COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF AS INHIBITORS OF RAN GTPASE

Compounds of general formula IA, IB and IC outlined below, including pharmaceutically acceptable salts, solvates and hydrates thereof. Such compounds and pharmaceutical compositions comprising them may be used in medical conditions involving Ran GTPase.