107880-74-0 Usage
Description
Famotidine Acid IMpurity, also known as F102250(P), is an impurity of Famotidine, a histamine H2-receptor antagonist and an antiulcerative agent. It is a white solid with specific chemical properties that differentiate it from the main compound.
Uses
Used in Pharmaceutical Industry:
Famotidine Acid IMpurity is used as a reference material for the development and validation of analytical methods, quality control, and stability testing of Famotidine in the pharmaceutical industry. Its presence in the final product needs to be monitored and controlled to ensure the safety, efficacy, and quality of the drug.
Used in Research and Development:
Famotidine Acid IMpurity is used as a research compound for studying the effects of impurities on the pharmacological properties, safety, and efficacy of Famotidine. This helps in understanding the potential impact of impurities on the drug's performance and developing strategies to minimize their presence in the final product.
Used in Quality Control:
Famotidine Acid IMpurity is used as a quality control standard to ensure the accuracy and reliability of analytical methods used in the quantification of Famotidine and its related impurities. This helps in maintaining the quality and consistency of the drug across different batches and manufacturers.
Used in Regulatory Compliance:
Famotidine Acid IMpurity is used in the regulatory process to demonstrate compliance with the guidelines and specifications set by regulatory authorities for the manufacture and distribution of Famotidine. This includes the assessment of impurities, their identification, and control to meet the required standards for drug safety and efficacy.
Check Digit Verification of cas no
The CAS Registry Mumber 107880-74-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,7,8,8 and 0 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 107880-74:
(8*1)+(7*0)+(6*7)+(5*8)+(4*8)+(3*0)+(2*7)+(1*4)=140
140 % 10 = 0
So 107880-74-0 is a valid CAS Registry Number.
107880-74-0Relevant articles and documents
Isothermal and nonisothermal decomposition of famotidine in aqueous solution
Junnarkar,Stavchansky
, p. 599 - 604 (1995)
The kinetics of hydrolysis of famotidine in aqueous solution was studied by isothermal and nonisothermal method over the pH range of 1.71 to 10.0. Nonisothermal kinetics was studied with the purpose of determining its use in the establishment of the expiration date of pharmaceutical preparations, particularly drugs in solutions and for assessment of stability characteristics of pharmaceutical formulations during the development stage. A comparison of isothermal(55, 70 and 85°C) and nonisothermal kinetics was performed. Aqueous solutions of famotidine were buffered at pH 1.71, 2.24, 2.66, 4.0, 8.5, 9.0 and 10.0 were used. In the nonisothermal studies, the temperature rate of the reaction was continuously varied throughout the experiment. The energies of activation were found to be in close agreement for isothermal and nonisothermal studies, indicating that nonisothermal studies may save considerable amount of time in the early stages of drug development and stability testing. Logk-pH profiles were constructed for 55, 70 and 85°C from the first-order rate constants obtained from isothermal studies at pH values ranging from 1.71 to 10.00. The pH-rate profile indicated that famotidine undergoes specific acid catalysis in the acidic region and general base catalysis in the alkaline region. Hydrolysis in the acidic and alkaline media resulted in the formation of four and five degradation products, respectively. A possible degradation pathway for the acidic and alkaline hydrolysis was discussed.
