107920-34-3

Basic information

• Product Name: acetic acid-[4-(3-nitro-phenoxy)-anilide]
• Synonyms: acetic acid-[4-(3-nitro-phenoxy)-anilide]
• CAS NO: 107920-34-3
• Molecular Weight: 272.26
• Mol File: 107920-34-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: acetic acid-[4-(3-nitro-phenoxy)-anilide](CAS DataBase Reference)
• NIST Chemistry Reference: acetic acid-[4-(3-nitro-phenoxy)-anilide](107920-34-3)
• EPA Substance Registry System: acetic acid-[4-(3-nitro-phenoxy)-anilide](107920-34-3)

Safety Data

• Hazardous Substances Data: 107920-34-3(Hazardous Substances Data)

Upstream product

• 402-67-5 3-fluoro-1-nitrobenzene 
• 103-90-2 4-acetaminophenol 
• 585-79-5 m-nitrobromobenzene 

Downstream Products

• 108669-38-1 4-(3-nitrophenoxy)phenylamine hydrochloride 

Relevant articles and documents

Synthesis and structure-activity relationships of trisubstituted phenyl urea derivatives as neuropeptide Y5 receptor antagonists

1-((1R,2R)-2-Hydroxy-1-methyl-2-phenylethyl)-1-methyl-3-(4-phenoxyphenyl)urea (1) was identified as a hit from the screening of the neuropeptide Y5 (NPY5) receptor. This lead was optimized for in vitro potency by changing the stereochemistry, the phenylethyl segment, the urea portion, and the 4-phenoxyphenyl group on the molecule. Over 40 analogues of 1 were prepared to study the structure-activity relationship for this series. The most potent compounds in this class have IC50S less than 0.1 nM at the NPY5 receptor (e.g., 40f, 44a, and 47). To determine the functional activity for this series of compounds, selected analogues were tested in a cellular assay measuring forskolin-induced cyclic AMP accumulation in 293 cells transfected with the human NPY5 receptor. All urea analogues tested in the functional assay acted as antagonists (e.g., 1, 32, 40a, and 44e).