107967-38-4

Basic information

• Product Name: (3R,4S)-1-[2-(dimethylamino)ethyl]-4-(4-methoxyphenyl)-2-oxo-7-(trifluoromethyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl acetate hydrochloride (1:1)
• Synonyms: cis-(+)-3-(Acetyloxy)-1-(2-(dimethylamino)ethyl)-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-7-(trifluoromethyl)-2H-1-benzazepin-2-one monohydrochloride
• CAS NO: 107967-38-4
• Molecular Formula: C₂₄H₂₇F₃N₂O₄*ClH
• Molecular Weight: 500.9383
• Mol File: 107967-38-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 568.6°C at 760 mmHg
• Flash Point: 297.7°C
• Vapor Pressure: 6.08E-13mmHg at 25°C
• CAS DataBase Reference: (3R,4S)-1-[2-(dimethylamino)ethyl]-4-(4-methoxyphenyl)-2-oxo-7-(trifluoromethyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl acetate hydrochloride (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,4S)-1-[2-(dimethylamino)ethyl]-4-(4-methoxyphenyl)-2-oxo-7-(trifluoromethyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl acetate hydrochloride (1:1)(107967-38-4)
• EPA Substance Registry System: (3R,4S)-1-[2-(dimethylamino)ethyl]-4-(4-methoxyphenyl)-2-oxo-7-(trifluoromethyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl acetate hydrochloride (1:1)(107967-38-4)

Safety Data

• Hazardous Substances Data: 107967-38-4(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 138456-81-2 (3R,4S-cis)-3-hydroxy-1-<2-(dimethylamino)ethyl>-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-7-(trifluoromethyl)-2H-1-benzazepin-2-one monohydrochloride 

Relevant articles and documents

Benzazepinone calcium channel blockers. 2. Structure-activity and drug metabolism studies leading to potent antihypertensive agents. Comparison with benzothiazepinones

As part of a program to discover potent antihypertensive analogues of diltiazem (3a), we prepared 1-benzazepin-2-ones (4). Benzazepinones competitively displace radiolabeled diltiazem, and show the same absolute stereochemical preferences at the calcium channel receptor protein. Derivatives of 4 containing a trifluoromethyl substituent in the fused aromatic ring show potent and long-acting antihypertensive activity. Studies of the metabolism of 4 lead to the metabolically stable antihypertensive calcium channel blockers 5a and 5c. Benzazepinone 5a is a longer acting and more potent antihypertensive agent than the second generation diltiazem analogue TA-3090 (3e).