108012-20-0

Basic information

• Product Name: 5-methyl-3-phenylbenzo[b]thiophene
• Synonyms: 5-methyl-3-phenylbenzo[b]thiophene
• CAS NO: 108012-20-0
• Molecular Weight: 224.326
• Mol File: 108012-20-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 5-methyl-3-phenylbenzo[b]thiophene(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methyl-3-phenylbenzo[b]thiophene(108012-20-0)
• EPA Substance Registry System: 5-methyl-3-phenylbenzo[b]thiophene(108012-20-0)

Safety Data

• Hazardous Substances Data: 108012-20-0(Hazardous Substances Data)

Upstream product

• 33046-45-6 1-phenyl-2-(p-tolylthio)ethanone 
• 100-47-0 benzonitrile 
• 476653-27-7 [2-(benzotriazol-1-ylmethylsulfanyl)-5-methylphenyl](phenyl)methanone 
• 106-45-6 para-thiocresol 
• 536-74-3 phenylacetylene 
• 16717-64-9 1-azidostyrene 
• 14315-14-1 5-methylthianaphthene 
• 109674-45-5 4-methyl-2,6-dioxo-8-phenylhexahydro-[1,3,2]oxazaborolo[2,3-b][1,3,2]oxazaborol-4-ium-8-uide 
• 24852-91-3 5-methyl-2-methylsulfanyl-benzophenone 
• 135564-58-8 (5-methyl-2-sulfanylphenyl)(phenyl)methanone 

Relevant articles and documents

Palladium-catalyzed phosphine-free direct C-H arylation of benzothiophenes and benzofurans involving MIDA boronates

With high regioselectivity, a series of benzoheterocyclic compounds were synthesized via palladiium-catalyzed phosphine-free C-H arylation of benzothiophenes/benzofurans with aryl MIDA boronates at 30-50 °C in moderate to excellent yields. MIDA boronates were used in C-H arylation of heterocycles for the first time. Under the optimal conditions, the benzothiophenes could be transformed into the β-arylbenzothiophenes, and the benzofurans gave only α-aryl-substituted products.

Novel syntheses of 2,3-disubstituted benzothiophenes

The sodium salts of o-sulfanylphenyl ketones 3a-g were treated with α-benzotriazol-1-ylalkyl chlorides 4a,b to give intermediates 5a-k in good yields. Compounds 5a-k, on treatment successively with LDA and Ti (0), gave benzothiophenes 7a-k.