108046-31-7Relevant articles and documents
Transformations microbiologiques, 5. Hydroxylation microbiologique de lactames, d'amides et d'imides monocycliques par le champignon Beauveria sulfurescens
Archelas, Alain,Furstoss, Roland,Srairi, Driss,Maury, Georges
, p. 234 - 238 (2007/10/02)
In this paper, we describe and comment on the results of the biohydroxylation of five, six and seven membered lactams, amides and imides by the fungus Beauveria sulfurescens.Analysis of the experimental results indicates that two distinct processes do presumably occur : i: Hydroxylation at position α to the nitrogen atom and, ii : hydroxylation of non activated carbon atoms.The first process would only occur when the second one is disfavoured for geometric reasons.The influence of the experimental conditions on the regioselectivity and on the reaction yields has been examined.The products obtained are generally not optically active.