108047-38-7Relevant articles and documents
Base-Promoted Synthesis of 2-Aryl Quinazolines from 2-Aminobenzylamines in Water
Chatterjee, Tanmay,Kim, Dong In,Cho, Eun Jin
, p. 7423 - 7430 (2018/07/29)
A transition-metal-free procedure for the synthesis of a highly valuable class of heteroaromatics, quinazolines, was developed by using easily available 2-aminobenzylamines and α,α,α-trihalotoluenes. The transformation proceeded smoothly in the presence of only sodium hydroxide and molecular oxygen in water at 100 °C, furnishing a variety of 2-aryl quinazolines. The crystallization process of the crude reaction mixture for the purification of the solid products circumvents huge solvent-consuming workup and column chromatographic techniques, which make the overall process more sustainable and economical.