1080662-59-4

Basic information

• Product Name: 5-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl)-3-(cyclopropylmethyl)-1,2,4-oxadiazole
• CAS NO: 1080662-59-4
• Molecular Weight: 459.762
• Mol File: 1080662-59-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl)-3-(cyclopropylmethyl)-1,2,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl)-3-(cyclopropylmethyl)-1,2,4-oxadiazole(1080662-59-4)
• EPA Substance Registry System: 5-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl)-3-(cyclopropylmethyl)-1,2,4-oxadiazole(1080662-59-4)

Safety Data

• Hazardous Substances Data: 1080662-59-4(Hazardous Substances Data)

Upstream product

• 152821-00-6 2-cyclopropyl-N'-hydroxyethanimidamide 
• 168273-05-0 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carbonyl chloride 

Relevant articles and documents

Bioisosteric replacement of the pyrazole 3-carboxamide moiety of rimonabant. A novel series of oxadiazoles as CB1 cannabinoid receptor antagonists

Based on the bioisosteric replacement of the pyrazole C3-carboxamide of rimonabant with a 5-alkyl oxadiazole ring, a novel class of oxadiazole derivatives with promising biological activity towards CB1 receptors was discovered. Among them, compounds with an alkyl linker containing a strong electron-withdrawing group (e.g., CF3) and a sterically favorable bulky group (e.g., t-butyl) exhibited excellent CB1 antagonism and selectivity, and thus might serve as potential candidates for further development as anti-obesity agents.