1081-50-1 Usage
Description
(2Z)-2-[(pyridin-4-ylcarbonyl)hydrazono]propanoic acid is a chemical compound with the molecular formula C11H12N2O3. It is a hydrazono compound, containing a hydrazone functional group with a pyridin-4-ylcarbonyl group attached to a propanoic acid moiety. (2Z)-2-[(pyridin-4-ylcarbonyl)hydrazono]propanoic acid has potential applications in various fields, including organic synthesis, pharmaceuticals, and as a chemical intermediate. Its unique structure and properties make it a promising candidate for further investigation and development in medicinal chemistry research.
Uses
Used in Organic Synthesis:
(2Z)-2-[(pyridin-4-ylcarbonyl)hydrazono]propanoic acid is used as a building block in organic synthesis for the creation of various complex organic molecules. Its hydrazono functional group allows for versatile chemical reactions, making it a valuable component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (2Z)-2-[(pyridin-4-ylcarbonyl)hydrazono]propanoic acid is used as a key intermediate in the development of new drugs. Its unique structure and potential biological activities make it a promising candidate for the treatment of various diseases and disorders. Researchers are actively exploring its potential as a therapeutic agent, particularly in the areas of oncology, infectious diseases, and neurological disorders.
Used as a Chemical Intermediate:
(2Z)-2-[(pyridin-4-ylcarbonyl)hydrazono]propanoic acid serves as an important chemical intermediate in the production of various specialty chemicals. Its versatility and reactivity make it a valuable precursor in the synthesis of dyes, pigments, and other functional materials.
Used in Medicinal Chemistry Research:
(2Z)-2-[(pyridin-4-ylcarbonyl)hydrazono]propanoic acid is a subject of interest in medicinal chemistry research due to its potential biological activities. Researchers are investigating its interactions with biological targets and evaluating its efficacy in various in vitro and in vivo models. (2Z)-2-[(pyridin-4-ylcarbonyl)hydrazono]propanoic acid's unique structure and properties make it a promising candidate for the development of novel therapeutic agents and drug delivery systems.
Check Digit Verification of cas no
The CAS Registry Mumber 1081-50-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,8 and 1 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1081-50:
(6*1)+(5*0)+(4*8)+(3*1)+(2*5)+(1*0)=51
51 % 10 = 1
So 1081-50-1 is a valid CAS Registry Number.
1081-50-1Relevant articles and documents
Synthesis and structural characterization of diorganotin(IV) esters with pyruvic acid isonicotinyl hydrazone and pyruvic acid salicylhydrazone Schiff bases
Yin, Han Dong,Hong, Min,Wang, Qi Bao,Xue, Sheng Cai,Wang, Da Qi
, p. 1669 - 1676 (2005)
Eight diorganotin esters of Schiff base ligands formulated as [R 2SnLY]2, where L1 is 4-NC5H 4CON2C(CH3) CO2 with Y = H 2O, R = Ph (1), PhCH2 (2)
Design and synthesis of highly active antimycobacterial mutual esters of 2-(2-isonicotinoylhydrazineylidene)propanoic acid
Korduláková, Jana,Krátky, Martin,Maixnerová, Jana,Pál, Adrián,Pflégr, Václav,Stola?íková, Ji?ina,Trejtnar, Franti?ek,Vin?ová, Jarmila
, (2021/12/21)
The combination of two active scaffolds into one molecule represents a proven approach in drug design to overcome microbial drug resistance. We designed and synthesized more lipophilic esters of 2-(2-isonicotinoylhydrazineylidene)propanoic acid, obtained from antitubercular drug isoni-azid, with various alcohols, phenols and thiols, including several drugs, using carbodiimide-mediated coupling. Nineteen new esters were evaluated as potential antimycobacterial agents against drug-sensitive Mycobacterium tuberculosis (Mtb.) H37 Rv, Mycobacterium avium and Mycobacterium kansasii. Selected derivatives were also tested for inhibition of multidrug-resistant (MDR) Mtb., and their mechanism of action was investigated. The esters exhibited high activity against Mtb. (minimum inhibitory concentrations, MIC, from ≤0.125 μM), M. kansasii, M. avium as well as MDR strains (MIC from 0.25, 32 and 8 μM, respectively). The most active mutual derivatives were derived from 4-chloro/phenoxy-phenols, triclosan, quinolin-8-ol, naphthols and terpene alcohols. The experiments identified enoyl-acyl carrier protein reductase (InhA), and thus mycobacterial cell wall biosynthesis, as the main target of the molecules that are activated by KatG, but for some compounds can also be expected adjunctive mechanism(s). Generally, the mutual esters have also avoided cytotoxicity and are promising hits for the discovery of antimycobacterial drugs with improved properties compared to parent isoniazid.
Synthesis and bacteriostatic activity of thiosemicarbazones and isonicotinoylhydrazones of pyruvic acid
Kryukova,Zelenin,Ertevtsian,Dobrego
, p. 1609 - 1611 (2007/10/04)
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