108123-02-0

Basic information

• Product Name: 3-Furancarboxylic acid, 2,5-dimethyl-4-phenyl-, ethyl ester
• CAS NO: 108123-02-0
• Molecular Formula: C15H16O3
• Molecular Weight: 244.29
• Mol File: 108123-02-0.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 3-Furancarboxylic acid, 2,5-dimethyl-4-phenyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Furancarboxylic acid, 2,5-dimethyl-4-phenyl-, ethyl ester(108123-02-0)
• EPA Substance Registry System: 3-Furancarboxylic acid, 2,5-dimethyl-4-phenyl-, ethyl ester(108123-02-0)

Safety Data

• Hazardous Substances Data: 108123-02-0(Hazardous Substances Data)

Upstream product

• 4187-87-5 1-Phenyl-2-propyn-1-ol 
• 141-97-9 ethyl acetoacetate 
• 705-60-2 (2-nitroprop-1-enyl)benzene 
• 29113-63-1 ethyl 2,5-dimethyl-3-furoate 
• 108-90-7 chlorobenzene 
• 10147-11-2 propargyl benzene 
• 89530-34-7 1-phenyl-3-trimethylsilylprop-2-yn-1-ol 
• 16169-88-3 1-phenylprop-2-ynyl acetate 
• 1122594-02-8 2-acetyl-3-phenyl-5-(trimethylsilyl)-4-pentynoic acid ethyl ester 
• 100-52-7 benzaldehyde 
• 1007476-32-5 sodium ethyl acetylacetate enolate 
• 546103-01-9 2-acetyl-4-nitro-3-phenyl-valeric acid ethyl ester 
• 705-60-2 1-phenyl-2-nitroprop-1-ene 
• 64712-07-8 2-acetyl-4-oxo-3-phenyl-valeric acid ethyl ester 

Downstream Products

• 111500-62-0 (+/-)(1Ξ,2Ξ)-1,4-dimethyl-6-phenyl-7-oxa-norborn-5-ene-2r,3c,5-tricarboxylic acid-5-ethyl ester-2,3-anhydride 
• 22665-76-5 (+/-)(1Ξ,2Ξ)-1,4-dimethyl-5-phenyl-7-oxa-norborn-5-ene-2r,3c-dicarboxylic acid-anhydride 
• 19842-57-0 2,5-dimethyl-3-phenylfurane 
• 104794-30-1 3-Carboxy-2,5-dimethyl-4-phenylfuran 
• 100797-41-9 (2,5-Dimethyl-4-phenyl-[3]furyl)-methanol 

Relevant articles and documents

Silver-free activation of ligated gold(I) chlorides: The use of [Me3NB12Cl11]- as a weakly coordinating anion in homogeneous gold catalysis

Phosphane and N-heterocyclic carbene ligated gold(I) chlorides can be effectively activated by Na[Me3NB12Cl11] (1) under silver-free conditions. This activation method with a weakly coordinating closo-dodecaborate anion was shown to be suitable for a large variety of reactions known to be catalyzed by homogeneous gold species, ranging from carbocyclizations to heterocyclizations. Additionally, the capability of 1 in a previously unknown conversion of 5-silyloxy-1,6-allenynes was demonstrated.

Copper-catalyzed, silver-mediated formal [3+2] cycloaddition of simple alkynes with β-ketoesters through propargylic C(sp3)-H functionalization

A copper-catalyzed propargylic [3+2] cycloaddition of simple alkynes with β-ketoesters through the propargylic C(sp3)-H functionalization has been realized. Under catalysis by CuI in combination with 1,10-phenanthroline hydrate as the ligand and Ag2CO3 as a bifunctional reagent (oxidant and base), the reaction proceeds smoothly with a broad substrate scope, thus providing a variety of highly functionalized furans in moderate to high yields. This represents the first successful example of the catalytic propargylic cycloaddition of simple alkynes with bisnucleophiles based on the propargylic C(sp3)-H functionalization strategy.

Synthesis of tetrasubstituted NH pyrroles and polysubstituted furans via an addition and cyclization strategy

The FeCl3-catalyzed addition and cyclization of enamino esters with nitroolefins provides a straightforward and general method for the synthesis of tetrasubstituted NH pyrroles. This novel method tolerates a wide range of functionality, and allows for rapid elaboration of the nitroolefins into a variety of substituted pyrroles in good yields. Further, an efficient KOAc-promoted addition and cyclization protocol toward substituted furans has been described as well. Georg Thieme Verlag Stuttgart · New York.