1082068-51-6

Basic information

• Product Name: 3-(4-thiomethoxyphenyl)-4-phenyl-1H-pyrrole-2,5.dione
• Synonyms: 3-(4-thiomethoxyphenyl)-4-phenyl-1H-pyrrole-2,5.dione
• CAS NO: 1082068-51-6
• Molecular Weight: 295.362
• Mol File: 1082068-51-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(4-thiomethoxyphenyl)-4-phenyl-1H-pyrrole-2,5.dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-thiomethoxyphenyl)-4-phenyl-1H-pyrrole-2,5.dione(1082068-51-6)
• EPA Substance Registry System: 3-(4-thiomethoxyphenyl)-4-phenyl-1H-pyrrole-2,5.dione(1082068-51-6)

Safety Data

• Hazardous Substances Data: 1082068-51-6(Hazardous Substances Data)

Upstream product

• 62936-31-6 (4-methylsulfanylphenyl)oxoacetic acid ethyl ester 
• 103-81-1 Benzeneacetamide 
• 100-68-5 methyl-phenyl-thioether 

Downstream Products

• 1082068-52-7 3-(4-methanesulfonylphenyl)-4-phenyl-1H-pyrrole-2,5.dione 
• 1208065-59-1 C₁₇H₁₃NO₃S 

Relevant articles and documents

Synthesis and PGE2 production inhibition of 1H-furan-2,5-dione and 1H-pyrrole-2,5-dione derivatives

3,4-Diphenyl-substituted 1H-furan-2,5-dione and 1H-pyrrole-2,5-dione derivatives were synthesized and evaluated for the inhibitory activities on LPS-induced PGE2 production in RAW 264.7 macrophage cells. Both 1H-furan-2,5-dione and 1H-pyrrole-2,5-dione rings as main scaffolds were easily obtained using one of three synthetic methods. Among the compounds investigated, 1H-3-(4-sulfamoylphenyl)-4-phenyl-pyrrole-2,5-dione (6l) showed a strong inhibitory activity (IC50 = 0.61 μM) of PGE2 production.