108211-28-5Relevant articles and documents
Synthesis of (R)- and (S)-3-benzyl-3-methyl-2-azetidinone in enantiomerically pure form
Cativiela,Diaz-de-Villegas,Galvez
, p. 1141 - 1144 (1992)
The diastereoselective methylation of the enolate of 10-dicyclohexylsulfamoylisobornyl-3-phenyl-2-cyanopropanoate is reported. This methylation was carried out under a variety of conditions to achieve a good yield and selectivity and the reaction product
Enantioselective biotransformation of α,α-disubstituted dinitriles to the corresponding 2-cyanoacetamides using Rhodococcus sp. CGMCC 0497
Wu, Zhong-Liu,Li, Zu-Yi
, p. 2133 - 2142 (2007/10/03)
A new application of nitrile-converting enzymes in the synthesis of optically active α,α-disubstituted-α-cyanoacetamides from α,α-disubstituted-malononitriles with whole cells of Rhodococcus sp. CGMCC 0497 is described. The products were obtained with enantiomeric excesses of up to >99%, and yields of up to 53%. They are very useful chiral intermediates especially for the synthesis of chiral α,α-disubstituted amino acids but have never been synthesized directly by chemical or enzymatic methods.
Highly enantioselective synthesis of α,α-disubstituted malonamic acids through asymmetric hydrolysis of dinitriles with Rhodococcus sp. CGMCC 0497
Wu, Zhong-Liu,Li, Zu-Yi
, p. 386 - 387 (2007/10/03)
Highly enantioselective hydrolysis of α,α-disubstituted malononitriles by the strain Rhodococcus sp. CGMCC 0497 expressing both nitrile hydratase and amidase activity to give (R)-α,α-disubstituted malonamic acids which could be converted to valuable (R)-
