108225-24-7

Basic information

• Product Name: 2-Propanol, 1-(octadecyloxy)-3-(phenylmethoxy)-
• CAS NO: 108225-24-7
• Molecular Formula: C28H50O3
• Molecular Weight: 434.703
• Mol File: 108225-24-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-Propanol, 1-(octadecyloxy)-3-(phenylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propanol, 1-(octadecyloxy)-3-(phenylmethoxy)-(108225-24-7)
• EPA Substance Registry System: 2-Propanol, 1-(octadecyloxy)-3-(phenylmethoxy)-(108225-24-7)

Safety Data

• Hazardous Substances Data: 108225-24-7(Hazardous Substances Data)

Upstream product

• 2930-05-4 Benzyloxymethyl-oxiran 
• 112-92-5 1-octadecanol 
• 16725-43-2 4-(n-octadecyloxymethyl)-2,2-dimethyl-1,3-dioxolane 
• 124133-84-2 Toluene-4-sulfonic acid 1-hydroxymethyl-2-octadecyloxy-ethyl ester 
• 63326-69-2 1-O-Octadecyl-2-O-p-toluenesulfonyl-3-O-trityl-glycerol 
• 86334-56-7 1-octadecyloxy-3-trityloxy-propan-2-ol 
• 3386-32-1 n-octadecyl p-toluenesulfonate 
• 544-62-7 batyl alcohol 
• 13071-59-5 3-benzyloxypropan-1,2-diol 
• 112-89-0 1-Bromooctadecane 
• 16245-97-9 octadecyl glycidyl ether 
• 20194-18-7 sodium phenyl-methanolate 
• 15028-56-5 4-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxolane 
• 100-44-7 benzyl chloride 

Downstream Products

• 111040-52-9 1-benzyl-2-(2,3-epoxypropyl)-3-octadecylglycerol 
• 131958-38-8 1-benzyloxymethyl-2-octadecyloxyethoxyacetic acid 
• 103383-67-1 1-β-D-arabinofuranosylcytosine 5'-diphosphate-rac-1-O-octadecyl-2-O-palmitoylglycerol 
• 90339-62-1 Phosphoric acid 2-methoxy-3-octadecyloxy-propyl ester phenyl ester 
• 84337-43-9 2-methoxy-3-octadecyloxy-1-propanol 
• 176683-47-9 Hexadecanoic acid 2-{(2-chloro-phenoxy)-[(2R,3S,4S,5R)-5-(4-hexadecanoylamino-2-oxo-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy]-phosphoryloxy}-1-octadecyloxymethyl-ethyl ester 
• 176683-45-7 Hexadecanoic acid 2-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-1-octadecyloxymethyl-ethyl ester 
• 90940-90-2 1-O-benzyl-2-O-methyl-3-O-octadecyl-rac-glycerol 
• 111040-58-5 3-benzyloxy-2-(2,2-dimethoxyethoxy)propyl octadecyl ether 

Relevant articles and documents

Synthesis of new carbohydrate-containing cationic alkyl glycerolipids with antitumor activity

New non-phosphorous carbohydrate-containing cationic alkyl glycerolipids bearing a terminal glycosyl moiety were synthesized. An approach used for the preparation of 2-O-ethyl-1-O-octadecyl-rac-glycerol allowed us to increase the yield of this key precursor by a factor of two. The carbohydrate-containing cationic alkyl glycerolipids induced tumor cell death and minimal damage to normal cells (in particular, erythrocytes), which makes the new compounds promising for practical purposes.

Synthesis of liposomal phospholipid-(N4-palmitoyl-1-β-D-arabinofuranosylcytosine) conjugates and evaluation of their cytostatic activity against L1210 murine leukemia

N4-Palmitoyl-araC, a prodrug of the cytostatic compound 1-β-D-arabinofuranosylcytosine (araC), was linked by means of the triester method to the phospholipids (2-chlorophenyl) (1,2-di-O-palmitoylglyceryl) phosphate, (2-chlorophenyl) (1,2-di-O-octadecylglyceryl) phosphate and (2-chlorophenyl) (1-O-octadecyl-2-O-palmitoylglyceryl) phosphate. In the first step of these gram-scale syntheses phospholipid-(N4-palmitoyl-araC) conjugates were obtained the linkage of which was accomplished via a triester group. In the second step the final condensates were obtained through transformation of the triester into a diester linkage by removal of the 2-chlorophenyl group. The cytostatic activity of these compounds which form stable liposomal preparations together with matrix lipids was evaluated according to the L1210 mouse leukemia model. The conjugates containing a triester linkage were shown to be ineffective, whereas those with a diester linkage display a significantly higher antitumor activity as compared to N4-palmitoyl-araC and araC. With the diester 6a-8a 80-100% of the treated animals were cured at a total dose of 200 μmol/kg, whereas with araC given at a fourfould higher concentration none of the treated mice survived. VCH Verlagsgesellschaft mbH, 1996.

Synthesis of glyceryletherphosphatides, 1st communication. Preparation of 1-0-octadecyl-2-0-acetyl-sn-glyceryl-3-phosphorylcholine ('platelet activating factor'), of its enantiomer and of some analogous compounds

-