108235-80-9

Basic information

• Product Name: Cyclohexanecarbonyl chloride, 5-methyl-2-(1-methylethyl)-, (1R,2S,5R)- (9CI)
• Synonyms: Cyclohexanecarbonyl chloride, 5-methyl-2-(1-methylethyl)-, (1R,2S,5R)- (9CI)
• CAS NO: 108235-80-9
• Molecular Formula: C₁₁H₁₉ClO
• Molecular Weight: 202.72096
• Product Categories: ACIDHALIDE
• Mol File: 108235-80-9.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 240.7±9.0 °C(Predicted)
• Appearance: /
• Density: 0.990±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Cyclohexanecarbonyl chloride, 5-methyl-2-(1-methylethyl)-, (1R,2S,5R)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanecarbonyl chloride, 5-methyl-2-(1-methylethyl)-, (1R,2S,5R)- (9CI)(108235-80-9)
• EPA Substance Registry System: Cyclohexanecarbonyl chloride, 5-methyl-2-(1-methylethyl)-, (1R,2S,5R)- (9CI)(108235-80-9)

Safety Data

• Hazardous Substances Data: 108235-80-9(Hazardous Substances Data)

Upstream product

• 16052-40-7 (-)-(1R,3R,4S)-4-isopropyl-1-methylcyclohexane-3-carboxylic acid 
• 15356-60-2 (1S,2R,5S)-(+)-menthol 
• 16052-42-9 (1R,2S,5R)-menthyl chloride 
• 63474-24-8 (1R,2S,5R)-(-)menthylmagnesium chloride 
• 663218-94-8 menthylformic acid 
• 2216-51-5 (-)-menthol 

Downstream Products

• 108340-97-2 meso-α,α,α,α-tetrakis<2-<(p-menth-3-ylcarbonyl)amino>phenyl>-porphyrin 
• 616867-10-8 (E)-4-(tert-Butyl-dimethyl-silanyloxy)-1-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-3-methyl-but-2-en-1-one 
• 616867-11-9 2,2-Dimethyl-propionic acid (E)-(R)-4-hydroxy-1-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-3-methyl-but-2-enyl ester 
• 616866-95-6 (E)-(R)-4-(tert-Butyl-dimethyl-silanyloxy)-1-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-3-methyl-but-2-en-1-ol 
• 616866-96-7 2,2-Dimethyl-propionic acid (E)-(R)-4-(tert-butyl-dimethyl-silanyloxy)-1-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-3-methyl-but-2-enyl ester 
• 616867-24-4 tert-Butyl-[(E)-(S)-2-isopropyl-4-((1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-2-methyl-but-3-enyloxy]-diphenyl-silane 
• 947258-18-6 C₁₈H₂₆N₂O₄ 
• 947258-28-8 C₁₉H₂₈BrNO 
• 947258-11-9 C₂₆H₃₉N₃O₅ 
• 1005326-52-2 C₂₅H₄₁N₃O₃S 
• 947258-26-6 C₂₂H₃₁N₃O₂ 
• 1070866-28-2 C₂₆H₃₇N₃O₆ 
• 1160173-10-3 (1R,2S,5R)-2-isopropyl-5-methyl-N-(3-(o-tolyloxy)propyl)cyclohexane-carboxamide 
• 27373-99-5 (1R)-2t-isopropyl-5c-methyl-cyclohexane-r-carboxylic acid amide 

Relevant articles and documents

Method for preparing menthane carboxamide by taking L-menthol as raw material

The invention relates to a method for preparing menthane carboxamide by taking L-menthol as a raw material. The menthane carboxamide is prepared through the processes of chlorination, a Grignard reaction, acidification, acylating chlorination, amidation, distillation, recrystallization and the like in sequence. The process route is mature, has the advantages of operation management simplicity andsecurity risk reduction, during a chlorination process, lower-layer waste acid water is collected and reduced pressure distillation is carried out; H2O and HCl in the acid water are removed; recoveryof ZnCl2 is realized, reduced pressure distillation completion is realized, and a reagent, namely concentrated HCl, is added into the recovered ZnCl2; a ZnCl2/HCl saturated solution is prepared again,the L-menthol is added for chlorination reaction again, the steps are repeated, the waste acid water in the chlorination reaction can be repeatedly used, the production cost is saved, the wastewatertreatment cost is reduced, and the economic benefit is improved.

SYNTHESIS OF ARYL CYCLOHEXANE CARBOXAMIDE DERIVATIVES USEFUL AS SENSATES IN CONSUMER PRODUCTS

Synthesis methods to produce a series of carboxamides built off of an (S)-2-amino acid backbone or an (R)-2-amino acid backbone, depending upon the desired diastereomer of the end product.

PROCESS FOR MAKING NEO-ENRICHED p-MENTHANE COMPOUNDS

A process for making neo-enriched p-menthane intermediates is disclosed. Lewis acid-catalyzed rearrangement of an oxaspiro compound provides an aldehyde mixture comprising normal (II) and neo (III) p-menthane-3-aldehydes: with the neo aldehyde (III) as the major product. The aldehyde mixture is readily oxidized to provide the corresponding carboxylic acids, and the acids are easily converted to a host of neo-enriched p-menthane esters or amides. The esters and amides are valuable as physiological coolants.