1082730-34-4

Basic information

• Product Name: (E)-N-methoxy-N-methyl-3-(3,4,5-trimethoxyphenyl)acrylamide
• Synonyms: (E)-N-methoxy-N-methyl-3-(3,4,5-trimethoxyphenyl)acrylamide
• CAS NO: 1082730-34-4
• Molecular Weight: 281.309
• Mol File: 1082730-34-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (E)-N-methoxy-N-methyl-3-(3,4,5-trimethoxyphenyl)acrylamide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-N-methoxy-N-methyl-3-(3,4,5-trimethoxyphenyl)acrylamide(1082730-34-4)
• EPA Substance Registry System: (E)-N-methoxy-N-methyl-3-(3,4,5-trimethoxyphenyl)acrylamide(1082730-34-4)

Safety Data

• Hazardous Substances Data: 1082730-34-4(Hazardous Substances Data)

Upstream product

• 124931-12-0 diethyl (N-methoxy-N-methylcarbamoylmethyl)phosphonate 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 20329-98-0 (E)-3,4,5-trimethoxy-cinnamic acid 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 682805-47-6 C₁₃H₁₄O₇ 
• 20329-96-8 methyl 3,4,5-trimethoxycinnamate 
• 1117-97-1 N,0-dimethylhydroxylamine 

Downstream Products

• 127034-55-3 1-phenyl-3-(3,4,5-trimethoxyphenyl)-trans-prop-2-en-1-one 
• 1352050-81-7 (E)-3-(3,4,5-trimethoxyphenyl)-1-4-[(E)-3-(3,4,5-trimethoxyphenyl)-2-propenoyl]piperazino-2-propen-1-one 
• 30687-11-7 (E)-N-(2-hydroxyethyl)-3-(3,4,5-trimethoxyphenyl)acrylamide 
• 1422251-50-0 (E)-N-(3-(2-oxopyrrolidin-1-yl)propyl)-3-(3,4,5-trimethoxyphenyl)acrylamide 
• 1703-34-0 (E)-1-(piperidin-1-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one 
• 1002861-65-5 (E)-1-(4-benzoylpiperazin-1-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one 
• 19856-60-1 (E)-1-(thiomorpholin-4-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one 

Relevant articles and documents

General Method for the Preparation of Indole-2-Weinreb Amides

Indole-2-Weinreb amides are obtained via thermolysis of α-azidocinnamic acid Weinreb amides in a Hemetsberger-Knittel-type cyclization. The required vinyl azides are not accessible by Knoevenagel condensation, but are obtained by cerium(IV)-mediated oxida

Synthesis and Evaluation of a Series of 3,4,5-Trimethoxycinnamic Acid Derivatives as Potential Antinarcotic Agents

A series of 3,4,5-trimethoxycinnamic acid derivatives was prepared and evaluated for antinarcotic effects on morphine dependence in mice and binding affinities on serotonergic receptors. The key synthetic strategies involve generation of ketones 6-7, esters 9-12 through condensation reaction, and amides 13-19 via coupling reaction using 1-hydroxybenzotriazole/ethyl(dimethylaminopropryl)carbodiimide system in high yield. We found that the naloxone-induced morphine withdrawal syndrome was significantly suppressed by new synthetic 3,4,5-trimethoxycinnamic acid derivatives (20mg/kg/day). Most of 3,4,5-trimethoxycinnamic acid derivatives were found to have high affinity to 5-HT1A receptor. The naloxone-induced morphine withdrawal syndrome was attenuated by (+)8-OH-DPAT (0.1mg/kg/day, i.p.), a 5-HT1A receptor agonist. In cortical neuronal cells, (+)8-OH-DPAT (1μm) produced an elevation of the pERK 1/2 expression, and the elevated pERK levels were inhibited by WAY 100635, a 5-HT1A receptor-specific antagonist. Interestingly, the pERK levels were increased by the 3,4,5-trimethoxycinnamic acid derivatives and the derivatives-mediated changes in pERK levels were blocked by the WAY 100635. These results suggested that new synthetic 3,4,5-trimethoxycinnamic acid derivatives have a potential antinarcotic effect through acting as a 5-HT1A receptor agonist in mice.