1082745-53-6

Basic information

• Product Name: 5-aMino-1-(4,4-difluorocyclohexyl)-1H-pyrazole-4-carbonitrile
• Synonyms: 5-aMino-1-(4,4-difluorocyclohexyl)-1H-pyrazole-4-carbonitrile
• CAS NO: 1082745-53-6
• Molecular Formula: C10H12F2N4
• Molecular Weight: 226.229
• EINECS: -0
• Mol File: 1082745-53-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 5-aMino-1-(4,4-difluorocyclohexyl)-1H-pyrazole-4-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-aMino-1-(4,4-difluorocyclohexyl)-1H-pyrazole-4-carbonitrile(1082745-53-6)
• EPA Substance Registry System: 5-aMino-1-(4,4-difluorocyclohexyl)-1H-pyrazole-4-carbonitrile(1082745-53-6)

Safety Data

• Hazardous Substances Data: 1082745-53-6(Hazardous Substances Data)

Upstream product

• 1214910-81-2 C₂HF₃O₂*C₆H₁₂F₂N₂ 
• 123-06-8 Ethoxymethylenemalononitrile 
• 1214910-72-1 N'-(4,4-difluorocyclohexyl)hydrazinecarboxylic acid tert-butyl ester 
• 22515-18-0 4,4-difluorocyclohexanone 

Downstream Products

• 1082745-54-7 5-amino-1-(4,4-difluoro-cyclohexyl)-1H-pyrazole-4-carboxylic acid amide 
• 1214910-26-5 C₂₀H₁₉F₂N₇O 
• 1214910-24-3 C₁₈H₁₉F₂N₅O*ClH 
• 1214910-10-7 C₁₈H₁₉F₂N₅O₂ 
• 1214909-62-2 C₂₅H₃₁F₂N₅O₂ 
• 1214908-07-2 C₁₇H₁₇F₂N₅O 
• 1214911-74-6 C₁₈H₁₇F₂N₅O₃ 
• 1214911-72-4 C₁₈H₁₉F₂N₅O₄ 

Relevant articles and documents

PYRAZOLO[3,4-D]PYRIMIDIN-4(5H)-ONE DERIVATIVES AS PDE9 INHIBITORS

A compound of the general formula (I) wherein R1 is selected from the group consisting of phenyl unsubstituted or substituted with 1 to 3 substituents selected from F, Cl, Br, I, CN, -O-C1-C3-alkyl, fluorinated -O-C1-C3-alkyl, -(CH2)mOH and 5-membered heterocyclic group with 1 or 2 heteroatoms selected from N, O and S; and 6- or 10-membered heteroaryl with 1 to 3 heteroatoms selected from O, N and S; R2 and R3 independently of each other represent H atom or straight or branched C1-C3 alkyl; R4 is selected from the group consisting of 4- to 6- membered cycloalkyl, wherein one of carbon atoms can be replaced by O atom, and which is unsubstituted or substituted with one or two halogen atoms,and straight or branched C1-C4 alkyl; Q represents a bond or C1-C3-alkylene, which can be optionally substituted by one to three C1-C3-alkyls; X is selected from the group consisting of O, NR5, and S(O)p; R5 represents H atom or C1-C3alkyl; m is 1, 2 or 3; p is 0, 1 or 2; and salts thereof, for use as a medicament, in particular for treating cognitive function disorders and neurodegenerative diseases.

NEW COMPOUNDS FOR THE TREATMENT OF CNS DISORDER

The invention relates to novel pyrazolopyrimidinones according to formula (I). The new compounds shall be used for the manufacture of medicaments, in particular medicaments for the treatment of conditions concerning deficits in perception, concentration, learning or memory. The new compounds are also for the manufacture of medicaments for the treatment of Alzheimer's disease. Further aspects of the present invention refer to a process for the manufacture of the compounds and their use for producing medicaments.

AMINO-HETEROCYCLIC COMPOUNDS

The invention provides PDE9-inhibiting compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein R, R1, R2 and R3 are as defined herein. Pharmaceutical compositions containing the compounds of Formul