108276-29-5Relevant articles and documents
One Step Synthesis of 5-Acylamino-2,2-dialkyl-4-oxo-1,3-dioxanes: A Cyclic System Enabling Simultaneous Protection of Hydroxyl and Carboxyl Functions in α-Hydroxymethyl-α-Amino Acids
Kaminski, Z. J.,Leplawy, M. T.
, p. 649 - 651 (2007/10/02)
N-Acyl-α-alkylserines 1 were heated with aliphatic acetals 2 in the presence of mineral acid to afford 5-acylamino-2,2-dialkyl-4-oxo-1,3-dioxanes 3.This cyclic system is stable enough to survive amino group deprotection as well as peptide coupling conditi