1083181-28-5 Usage
General Description
Ethyl 5-chloro-7-azaindole-3-carboxylate, often shortened to ECA, is an organic compound often used in chemical reactions in the laboratory, particularly in pharmaceutical and medicinal chemistry research. This chemical is known for its role as an intermediate in the synthesis of several medicinally important compounds. Its properties include a molecular weight of 234.68 g/mol, a mono-isotopic mass of 234.011841 g/mol, and a covalently-bonded unit count of 1. It falls in the category of halopyridines and is typically a solid substance at room temperature. In some cases, it may be referred to by its CAS Registry Number, which is 144060-53-7.
Check Digit Verification of cas no
The CAS Registry Mumber 1083181-28-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,8,3,1,8 and 1 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1083181-28:
(9*1)+(8*0)+(7*8)+(6*3)+(5*1)+(4*8)+(3*1)+(2*2)+(1*8)=135
135 % 10 = 5
So 1083181-28-5 is a valid CAS Registry Number.
1083181-28-5Relevant articles and documents
Indirect C-H azidation of heterocycles via copper-catalyzed regioselective fragmentation of unsymmetrical λ3-iodanes
Lubriks, Dmitrijs,Sokolovs, Igors,Suna, Edgars
supporting information, p. 15436 - 15442 (2012/10/29)
A C-H bond of electron-rich heterocycles is transformed into a C-N bond in a reaction sequence comprising the formation of heteroaryl(phenyl)iodonium azides and their in situ regioselective fragmentation to heteroaryl azides. A Cu(I) catalyst ensures complete regiocontrol in the fragmentation step and catalyzes the subsequent 1,3-dipolar cycloaddition of the formed azido heterocycles with acetylenes. The heteroaryl azides can also be conveniently reduced to heteroarylamines by aqueous ammonium sulfide. The overall C-H to C-N transformation is a mild and operationally simple one-pot sequential multistep process.