108349-24-2Relevant articles and documents
Radical additions of acyclic and cyclic ethers to alkenes via an allyl transfer reaction involving phthalimido-N-oxyl radical
Patil, Shradha V.,Tanko, James M.
, p. 7849 - 7858 (2016)
Direct functionalization of rudimentary and cheap starting materials to yield complex value added products is of great interest to synthetic chemists. Particularly, direct functionalization of cheap commodity molecules that have been traditionally considered inert to known reactions are of widespread interest. We have previously demonstrated the functionalization of benzylic C–H bonds via an allyl transfer reaction using various allyl-phthalimido-N-oxyl substrates. In this work, we demonstrate the extension of our mild, metal-free, and neutral allyl transfer methodology to the direct functionalization of ethers. The C–H bond in α position to the ether oxygen in various acyclic and cyclic ethers was functionalized in high yields demonstrating wide substrate scope for this transformation. Furthermore, selective mono-functionalization of symmetrical cyclic ethers and regioselective functionalization of unsymmetrical ethers was achieved, thus demonstrating further utility of this reaction. Finally, kinetic chain length measurements were performed, which provided valuable insights into the initial rates and efficiency of the chain process involving the phthalimido-N-oxyl (PINO[rad]) radical.
Method for preparing allyl ketone compound through visible light and cobalt synergistic catalysis
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Paragraph 0039-0056, (2020/07/21)
The invention discloses a method for preparing an allyl ketone compound through visible light and cobalt synergistic catalysis. The method comprises the following steps: using alpha-carbonyl carboxylic acid and methacrylate olefin as reaction substrates; dissolving potassium tert-butoxide or 2, 6-dimethylpyridine serving as alkali, using 4-CzIPN as a visible-light-induced photocatalyst and using acobalt complex as a synergistic catalyst in a solvent to obtain a mixed solution, and irradiating the mixed solution with visible light under the protection of inert gas to obtain the allyl ketone compound. The reaction can be realized by visible light irradiation at room temperature, the method is simple and convenient to operate, the raw materials are easy to obtain, the whole reaction system is very green and environmentally friendly, reaction conditions are mild, the reaction can be completed under the action of a catalytic amount of the photocatalyst and the cobalt complex, equivalent additional oxidants are not needed, the reaction system is efficient and economical and is suitable for gram-level reaction on an amplified large scale and has huge potential large-scale application value.
A SIMPLE AND GENERAL APPROACH FOR THE SYNTHESIS OF 2-SUBSTITUTED 4-ETHOXYCARBONYLFURAN
Anand, Ramesh C.,Singh, Vibha
, p. 1333 - 1336 (2007/10/02)
A four step strategy has been devised to synthesize 2-substituted 4-ethoxycarbonylfuran starting from an aldehyde.
