108375-77-5 Usage
Description
PC 766B is a 16-membered macrolide antibiotic derived from Nocardia brasiliensis, featuring a unique butadiene side-chain and belonging to the bafilomycin class. It exhibits activity against Gram-positive bacteria, certain fungi, and yeasts, while showing no effect on Gram-negative bacteria. Additionally, PC 766B demonstrates antitumor properties against murine tumor cells both in vitro and in vivo, albeit with weak inhibitory activity against Na/K-ATPase compared to related antibiotics.
Uses
Used in Pharmaceutical Industry:
PC 766B is used as an antibiotic for its effectiveness against Gram-positive bacteria, fungi, and yeasts, making it a valuable asset in the treatment of various infections caused by these microorganisms.
Used in Oncology Research:
PC 766B is used as an antitumor agent in the study and treatment of cancer, particularly in the context of mouse P388 leukemia and B16 melanoma cells. Its in vitro and in vivo activity against these tumor cells highlights its potential in cancer research and therapeutic development.
Used in Biochemical Research:
Due to its weak inhibitory activity against Na/K-ATPase, PC 766B can be utilized in biochemical research to study the function and inhibition of this essential enzyme, which plays a crucial role in maintaining cellular ion balance and overall cellular function.
references
[1] kumagai k, taya k, fukui a, et al. pc-766b, a new macrolide antibiotic produced by nocardia brasiliensis[j]. the journal of antibiotics, 1993, 46(6): 972-978.
Check Digit Verification of cas no
The CAS Registry Mumber 108375-77-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,8,3,7 and 5 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 108375-77:
(8*1)+(7*0)+(6*8)+(5*3)+(4*7)+(3*5)+(2*7)+(1*7)=135
135 % 10 = 5
So 108375-77-5 is a valid CAS Registry Number.
InChI:InChI=1/C43H68O12/c1-12-13-14-17-33-28(6)36(53-37-22-32(44)40(47)31(9)52-37)23-43(49,55-33)30(8)39(46)29(7)41-34(50-10)18-15-16-24(2)19-26(4)38(45)27(5)20-25(3)21-35(51-11)42(48)54-41/h12-18,20-21,26-34,36-41,44-47,49H,19,22-23H2,1-11H3/b13-12+,17-14+,18-15-,24-16-,25-20-,35-21-/t26-,27+,28+,29?,30-,31+,32+,33+,34-,36+,37+,38-,39+,40+,41+,43+/m0/s1
