108433-95-0 Usage
Description
Magainin II is a member of the antimicrobial peptides family, characterized by its cationic nature and unique amino acid sequence. It is water-soluble, non-hemolytic at effective concentrations, and possesses amphiphilic properties that contribute to its antimicrobial activity.
Uses
Used in Pharmaceutical Industry:
Magainin II is used as an antimicrobial agent for its ability to effectively target and neutralize a wide range of pathogens, including bacteria, fungi, and viruses. Its cationic and amphiphilic properties allow it to disrupt the cell membranes of these microorganisms, leading to their destruction.
Used in Cosmetics Industry:
In the cosmetics industry, Magainin II is used as a preservative due to its potent antimicrobial properties. It helps maintain the integrity of cosmetic products by preventing the growth of harmful microorganisms, ensuring product safety and shelf life.
Used in Food Industry:
Magainin II is utilized as a natural preservative in the food industry to enhance the shelf life of perishable items. Its ability to inhibit the growth of various microorganisms helps maintain the freshness and quality of the food products while reducing the reliance on synthetic additives.
Used in Medical Applications:
Magainin II is employed in the development of wound dressings and other medical applications due to its antimicrobial and non-hemolytic properties. It can help prevent infection and promote healing in various medical conditions, such as burns, ulcers, and surgical wounds.
Biochem/physiol Actions
Magainin II acts as an antibiotic in a variety of organisms. Magainin II exhibits cytotoxic and anti-proliferative effects via pore formation in bladder cancer cells. In mice, it acts as an anti-tumor agent in several cancer cell lines and tumors. Magainin II facilitates lactate dehydrogenase discharge from mammalian cells. It directly interacts with certain cell membranes via amphiphilic α-helix and forms permeable ion channels, which results in depolarization and irreversible cytolysis and finally cell death. At low concentrations, Magainin II retards the growth of bacterial and fungal species and it promotes cytolysis in protozoa.
Check Digit Verification of cas no
The CAS Registry Mumber 108433-95-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,8,4,3 and 3 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 108433-95:
(8*1)+(7*0)+(6*8)+(5*4)+(4*3)+(3*3)+(2*9)+(1*5)=120
120 % 10 = 0
So 108433-95-0 is a valid CAS Registry Number.
InChI:InChI=1/C114H180N30O29S/c1-12-65(7)94(142-88(148)55-119)112(170)124-59-90(150)129-74(38-24-28-45-116)100(158)137-81(51-70-33-19-15-20-34-70)106(164)135-79(49-63(3)4)105(163)138-83(53-72-56-121-62-125-72)107(165)140-85(60-145)110(168)127-67(9)96(154)131-75(39-25-29-46-117)101(159)132-76(40-26-30-47-118)102(160)136-80(50-69-31-17-14-18-32-69)98(156)122-57-89(149)128-73(37-23-27-44-115)99(157)126-68(10)97(155)134-82(52-71-35-21-16-22-36-71)109(167)143-93(64(5)6)111(169)123-58-91(151)130-77(41-42-92(152)153)104(162)144-95(66(8)13-2)113(171)133-78(43-48-174-11)103(161)139-84(54-87(120)147)108(166)141-86(61-146)114(172)173/h14-22,31-36,56,62-68,73-86,93-95,145-146H,12-13,23-30,37-55,57-61,115-119H2,1-11H3,(H2,120,147)(H,121,125)(H,122,156)(H,123,169)(H,124,170)(H,126,157)(H,127,168)(H,128,149)(H,129,150)(H,130,151)(H,131,154)(H,132,159)(H,133,171)(H,134,155)(H,135,164)(H,136,160)(H,137,158)(H,138,163)(H,139,161)(H,140,165)(H,141,166)(H,142,148)(H,143,167)(H,144,162)(H,152,153)(H,172,173)/t65-,66-,67-,68-,73-,74-,75
