108446-69-1

Basic information

• Product Name: 2-(1-Phenyl-3-p-tolyl-1H-pyrazol-4-ylmethylene)-malonic acid
• Synonyms: 2-(1-Phenyl-3-p-tolyl-1H-pyrazol-4-ylmethylene)-malonic acid
• CAS NO: 108446-69-1
• Molecular Weight: 348.358
• Mol File: 108446-69-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(1-Phenyl-3-p-tolyl-1H-pyrazol-4-ylmethylene)-malonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-Phenyl-3-p-tolyl-1H-pyrazol-4-ylmethylene)-malonic acid(108446-69-1)
• EPA Substance Registry System: 2-(1-Phenyl-3-p-tolyl-1H-pyrazol-4-ylmethylene)-malonic acid(108446-69-1)

Safety Data

• Hazardous Substances Data: 108446-69-1(Hazardous Substances Data)

Upstream product

• 141-82-2 malonic acid 
• 36640-52-5 1-phenyl-3-(p-tolyl)-1H-pyrazole-4-carbaldehyde 
• 54779-81-6 4-methylacetophenone phenylhydrazone 
• 108446-87-3 2-(1-Phenyl-3-p-tolyl-1H-pyrazol-4-ylmethylene)-malonic acid diethyl ester 

Downstream Products

• 108446-81-7 3-(1-Phenyl-3-p-tolyl-1H-pyrazol-4-yl)-propionic acid 
• 108446-74-8 (E)-3-(1-Phenyl-3-p-tolyl-1H-pyrazol-4-yl)-acrylic acid 

Relevant articles and documents

Azoles. 17. Beta-(4-pyrazol)acrylic and propionic acids and their anti-inflammatory activity

beta-(4-Pyrazole)acrylic acids 22-28 were prepared by the Knoevenagel reaction of malonic acid and 4-formylpyrazoles 8-14. 4-Pyrazolemethylenemalonic acids 15-21 were isolated as intermediates. The latter compounds were also synthesized by treating the 4-formylpyrazoles 8-14 with diethyl malonate followed by hydrolysis of the obtained diethyl esters 15a-21a. The effect of piperidine and pyridine on the Knoevenagel condensation was investigated. The beta-(4-pyrazole)acrylic acids 22-27, on catalytic reduction, gave the corresponding beta-(4-pyrazole)propionic acids 29-34. Compounds 23, 24, 27, 29-31 and 34 appeared to be less active than phenylbutazone in carrageenin-induced oedema test, but they were less toxic than the reference drug.